Recombinant Human CALML3 Protein (His tag) 100µg

• Catalog number
  PKSH030828-100µg
• Price
  Please ask
• Size
  100µg

• Synonym
  CLP
• Activity
  NA
• Sequence
  Met 1-Lys 149
• Fusion tag
  N-His
• Accession
  P27482
• Expressed Host
  E. coli
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞95 % as determined by SDS-PAGE
• Endotoxin
  Please contact us for more information.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  18.7kDa
• AP Mol Mass
  16 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Reconstitution
  Please refer to it for detailed information.
• Background
  Calmodulin-like protein 3 (CALML3) is similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinity, to cellular substrates. Calmodulin-like protein 3 (CALML3) is a tumor-sensitive protein specifically expressed in normal epithelial cells but downregulated in tumorigenesis. Downregulation of the protein is an early event in breast cancer development. One of the most pressing questions raised by the discovery of CLP/CALML3 is that of its potential targets. Although it is 85% identical to human calmodulin, the distinct properties of CLP suggest that it has specific targets or targets that only partially overlap with those of calmodulin. Research has identified the unconventional myosin-10 (Myo10) as a specific target of CALML3. The discovery of Myo10 as a specific target of CALML3 is highly significant and suggests multiple lines of further research such as investigations of the Ca2+ regulation of Myo10 and the role of the loss of CLP in epithelial differentiation, adhesion, and cancer. Cells expressing CALML3 displayed a striking increase in the number and length of myosin-10-positive filopodia and showed increased mobility in a wound healing assay.
• Product URL
• PDF URL
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  CALML3   Protein   His   tag   100µg  
• Gene symbol
  CALML3-AS1, CALML3
• Short name
  Recombinant CALML3 Protein (His tag) 100µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens CALML3 Protein (histidine detection labelled) 100µg
• Alternative technique
  rec

Gene info

• Identity
  HGNC:44682
• Gene
  CALML3-AS1
• Long gene name
  CALML3 antisense RNA 1
• GenBank acession
  • DA220455
  • DA770774
• Locus
  10p15.1
• Discovery year
  2012-12-04
• Entrez gene record
  100132159
• Pubmed identfication
  • 31298313
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000168090

Gene info

• Identity
  HGNC:1452
• Gene
  CALML3
• Long gene name
  calmodulin like 3
• Synonyms gene name
  • calmodulin-like 3
• Synonyms
  • CLP
• GenBank acession
  • X13461
• Locus
  10p15.1
• Discovery year
  1993-07-27
• Entrez gene record
  810
• Pubmed identfication
  • 8476923
• RefSeq identity
  • NM_005185
• Classification
  • EF-hand domain containing
• VEGA ID
  OTTHUMG00000017597

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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