Rat Angiotensinogen / SerpinA8 / AGT Protein (His Tag)
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Catalog numberPKSR030134-20µg
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PricePlease ask
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Size20µg
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SynonymSerpina8
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ActivityNA
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SequenceMet1-Val477
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Fusion tagC-His
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AccessionNP_602308.1
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ExpressedHostHEK293 Cells
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ShippingIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity> 95 % as determined by SDS-PAGE.
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Endotoxin< 1.0 EU per μg protein as determined by the LAL method.
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Stability and StorageSamples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass51 kDa
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AP Mol Mass51 kDa
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FormulationLyophilized from sterile PBS, pH 7.4
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BackgroundAngiotensinogen, also known as AGT and SerpinA8, is a member of the serpin family. It is an α-2-globulin that is produced constitutively and released into the circulation mainly by the liver. Angiotensinogen is a essential component of the renin-angiotensin system (RAS) and a potent regulator of blood pressure. Angiotensinogen can be schematically considered to consist of a combination of an angiotensin I (Ang I) function, located at the N-terminal end, and the presence of a serpin (serine protease inhibitor) structure at the opposite end. Angiotensinogen is cleaved into three chains: Angiotensin-1 (Ang I), Angiotensin-2 (Ang II), and Angiotensin-3 (Ang III). Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-7 is cleaved from angiotensin-2 by ACE2. Angiotensin-2 acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system. Defects in AGT are associated with susceptibility to essential hypertension and renal tubular dysgenesis (RTD). Several serpins (antithrombin, maspin, pigment epithelial-derived factor, and kallistatin) have been recently shown to exert an antiangiogenic activity, suggesting a common mechanism of endothelial cell proliferation and migration. Angiotensinogen/AGT and its renin-cleaved product, des(Ang I)AGT, are also angiogenesis inhibitors, both in vitro and in vivo at concentrations within the range of those observed in plasma. The Angiotensinogen products, that is angiotensin II and possibly angiotensin II-related products, have been found to act locally in modulating adipose tissue growth in an autocrine/paracrine manner. The transient or chronic overexpression of angiotensinogen in adipose tissue favors lipogenesis in adipocytes and leads to a 'vicious' circle whereby adipose tissue development is further increased.
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Conjugationhistidine
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AboutRats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
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Latin nameRattus norvegicus
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Gene target
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Gene symbolAGT, SLC7A13, AGXT, TRT-AGT3-1, TRT-AGT2-1, TRT-AGT2-2, TRT-AGT1-3, TRT-AGT7-1, TRT-AGT1-1, TRT-AGT1-2
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Short nameAngiotensinogen / SerpinA8 / AGT Protein (His Tag)
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TechniqueTags
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HostRat
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LabelHis
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SpeciesRat, Rats
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Alternative nameRat Angiotensinogen / SerpinA8 / angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Protein (histidine detection labelled)
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Alternative to gene targetangiotensinogen (serpin peptidase inhibitor, clade A, member 8), ANHU and SERPINA8, AGT and IDBG-107363 and ENSG00000135744 and 183, type 2 angiotensin receptor binding, Extracellular, Agt and IDBG-200169 and ENSMUSG00000031980 and 11606, AGT and IDBG-632058 and ENSBTAG00000012393 and 527114
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Gene info
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Identity
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Gene
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Long gene nameangiotensinogen
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Synonyms gene
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Synonyms gene name
- serpin peptidase inhibitor, clade A, member 8
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Synonyms name
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GenBank acession
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Locus
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Discovery year1989-06-30
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Neuropeptides
- Serpin peptidase inhibitors
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namesolute carrier family 7 member 13
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Synonyms gene name
- solute carrier family 7 (anionic amino acid transporter), member 13
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-09-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Solute carriers
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namealanine--glyoxylate and serine--pyruvate aminotransferase
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Synonyms gene
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Synonyms gene name
- serine:pyruvate aminotransferase
- alanine-glyoxylate aminotransferase
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1990-11-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nametrRNA-Thr (anticodon AGT) 3-1
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Synonyms gene
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Synonyms gene name
- transfer RNA threonine 21 (anticodon AGU)
- transfer RNA-Thr (AGT) 3-1
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Synonyms
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GenBank acession
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Locus
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Discovery year2008-08-29
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Entrez gene record
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Classification
- Cytoplasmic transfer RNAs
Gene info
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Identity
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Gene
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Long gene nametRNA-Thr (anticodon AGT) 2-1
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Synonyms gene
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Synonyms gene name
- transfer RNA threonine 14 (anticodon AGU)
- transfer RNA-Thr (AGT) 2-1
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Synonyms
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GenBank acession
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Locus
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Discovery year2008-08-29
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Entrez gene record
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Classification
- Cytoplasmic transfer RNAs
Gene info
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Identity
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Gene
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Long gene nametRNA-Thr (anticodon AGT) 2-2
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Synonyms gene
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Synonyms gene name
- transfer RNA threonine 15 (anticodon AGU)
- transfer RNA-Thr (AGT) 2-2
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Synonyms
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GenBank acession
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Locus
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Discovery year2008-08-29
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Entrez gene record
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Classification
- Cytoplasmic transfer RNAs
Gene info
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Identity
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Gene
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Long gene nametRNA-Thr (anticodon AGT) 1-3
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Synonyms gene
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Synonyms gene name
- transfer RNA threonine 4 (anticodon AGU)
- transfer RNA-Thr (AGT) 1-3
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Synonyms
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GenBank acession
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Locus
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Discovery year2008-08-29
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Entrez gene record
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Classification
- Cytoplasmic transfer RNAs
Gene info
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Identity
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Gene
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Long gene nametRNA-Thr (AGT) 7-1
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Synonyms gene
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Synonyms gene name
- tRNA threonine (AGU) 3
- transfer RNA threonine 3 (anticodon AGU)
- transfer RNA-Thr (AGT) 7-1
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-05-24
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Entrez gene record
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Pubmed identfication
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Classification
- Low confidence cytoplasmic transfer RNAs
Gene info
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Identity
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Gene
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Long gene nametRNA-Thr (anticodon AGT) 1-1
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Synonyms gene
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Synonyms gene name
- transfer RNA threonine 8 (anticodon AGU)
- transfer RNA-Thr (AGT) 1-1
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Synonyms
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GenBank acession
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Locus
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Discovery year2008-08-29
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Entrez gene record
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Classification
- Cytoplasmic transfer RNAs
Gene info
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Identity
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Gene
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Long gene nametRNA-Thr (anticodon AGT) 1-2
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Synonyms gene
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Synonyms gene name
- transfer RNA threonine 9 (anticodon AGU)
- transfer RNA-Thr (AGT) 1-2
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Synonyms
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GenBank acession
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Locus
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Discovery year2008-08-29
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Entrez gene record
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Classification
- Cytoplasmic transfer RNAs
