-
Long name
Rabbit Antibody against Human, Mouse HM13, Non-conjugated
-
Synonym name
HM13 Human, Mouse Antibody
-
Species reactivity
Human,Mouse
-
Tested applications recommended dilutions
ELISA,WB,IF;Recommended dilution:WB:1:1000-1:5000,IF:1:50-1:200
-
Conjugation
Non-conjugated
-
Antibody isotype
IgG
-
UniProt ID
Q8TCT9
-
Format
Liquid, diluted in buffer
-
Buffer composition
Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
-
Purity
>95%
-
Purification method
Protein G purified
-
Antibody category
Polyclonal Antibodies
-
Immunogen type
Recombinant human Minor histocompatibility antigen H13 protein (336-377AA)
-
Immunogen species
Human
-
Alias
Minor histocompatibility antigen H13 (EC:3.4.23.-),HM13,H13,IMP1,PSL3,SPP,MSTP086,Intramembrane protease 1,IMP-1,IMPAS-1,hIMP1,Presenilin-like protein 3,Signal peptide peptidase
-
Background
Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides (PubMed:11714810). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein (PubMed:12145199). Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:12077416, PubMed:11714810, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (PubMed:25239945). May play a role in graft rejection (By similarity).
-
Clonality
Polyclonal antibody
-
Shipping and storage
HM13 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
-
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
-
Properties
If you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
-
Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
-
Latin name
Mus musculus, Oryctolagus cuniculus
-
About
Rabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
-
French translation
anticorps
-
Gene target
-
Gene symbol
HM13-AS1, HM13-IT1, HM13
-
Short name
Anti-HM13
-
Technique
anti human, Antibody, Rabbit, Mouse, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, antibody Conjugates, mouses
-
Host
Rabbit, Rabbits
-
Species
Mouse, Humans, Mouses
-
Alternative name
HM13 Antibody
-
Alternative technique
antibodies, rabbit-anti, murine
-
Alternative to gene target
histocompatibility (minor) 13, HM13 and IDBG-62948 and ENSG00000101294 and 81502, aspartic endopeptidase activity, Cell surfaces, H13 and IDBG-209822 and ENSMUSG00000019188 and 14950, HM13 and IDBG-641527 and ENSBTAG00000008840 and 512534
-