Rabbit Anti Human RIPK2 Antibody-HRP
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Catalog numberCSB-PA019736LB01HU_100ug
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Price:
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Size100ug
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Long nameRabbit Antibody against Human RIPK2, HRP
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Synonym nameRIPK2 Human Antibody
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Species reactivityHuman
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Tested applications recommended dilutionsELISA
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ConjugationHRP
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Antibody isotypeIgG
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UniProt IDO43353
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FormatLiquid, diluted in buffer
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Buffer compositionPreservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
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Purity>95%
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Purification methodProtein G purified
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Antibody categoryPolyclonal Antibodies
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Immunogen typeRecombinant human Receptor-interacting serine/threo nine-protein kinase 2 protein (1-540AA)
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Immunogen speciesHuman
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AliasCARD-containing interleukin-1 beta-converting enzyme-associated kinase RIP-like-interacting CLARP kinase Receptor-interacting protein 2 Tyrosine-protein kinase RIPK2 EC=2.7.10.2 RIPK2 CARDIAK, RICK, RIP2 UNQ277/PRO314/PRO34092
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BackgroundSerine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
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ClonalityPolyclonal antibody
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Shipping and storageRIPK2 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
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PropertiesIf you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. HRP conjugates are often primary rabbit polyclonal antibodies couples to the enzyme horseradish peroxidase (HRP), found in the roots of horseradish. Also monoclonal HRP conjugates are often used for Western Blot. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional conjugationHRP Conjugated
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AboutRabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin nameOryctolagus cuniculus
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French translationanticorps
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Gene target
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Gene symbolRIPK2-DT, RIPK2
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Short nameAnti-RIPK2
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Techniqueanti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for
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HostRabbit, Rabbits
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LabelHRP
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SpeciesHuman, Humans
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Alternative nameRIPK2 Antibody,HRP conjugated
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Alternative techniqueantibodies, rabbit-anti
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Alternative to gene targetreceptor-interacting serine-threonine kinase 2, CARD3 and CARDIAK and CCK and GIG30 and RICK and RIP2, RIPK2 and IDBG-27941 and ENSG00000104312 and 8767, transferase activity, Cytoplasm, Ripk2 and IDBG-130745 and ENSMUSG00000041135 and 192656, RIPK2 and IDBG-645358 and ENSBTAG00000015271 and 534407
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Gene info
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Identity
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Gene
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Long gene nameRIPK2 divergent transcript
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Locus
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Discovery year2021-03-24
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Entrez gene record
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RefSeq identity
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Classification
- Divergent transcripts
Gene info
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Identity
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Gene
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Long gene namereceptor interacting serine/threonine kinase 2
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Synonyms gene name
- receptor-interacting serine-threonine kinase 2
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-05-07
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Entrez gene record
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Pubmed identfication
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Classification
- Caspase recruitment domain containing
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data