Rabbit Anti Human CISH Antibody-Non-conjugated
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Catalog numberCSB-PA885721ESR1HU_100ul
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PricePlease ask
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Size100ul
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Long nameRabbit Antibody against Human CISH, Non-conjugated
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Synonym nameCISH Human Antibody
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Species reactivityHuman
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Tested applications recommended dilutionsELISA,IHC;Recommended dilution:IHC:1:20-1:200
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ConjugationNon-conjugated
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Antibody isotypeIgG
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UniProt IDQ9NSE2
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FormatLiquid, diluted in buffer
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Buffer compositionPBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Purity>95%
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Purification methodAntigen Affinity Purified Antibodies
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Antibody categoryPolyclonal Antibodies
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Immunogen typeRecombinant human Cytokine-inducible SH2-containing protein (1-257AA)
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Immunogen speciesHuman
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AliasCIS,CIS-1,Protein G18,Suppressor of cytokine signaling,SOCS,CISH,G18
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BackgroundSOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
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ClonalityPolyclonal antibody
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Shipping and storageCISH Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
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PropertiesIf you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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AboutRabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin nameOryctolagus cuniculus
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French translationanticorps
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Gene target
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Gene symbolCISH
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Short nameAnti-CISH
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Techniqueanti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, antibody Conjugates
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HostRabbit, Rabbits
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SpeciesHuman, Humans
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Alternative nameCISH Antibody
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Alternative techniqueantibodies, rabbit-anti
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Alternative to gene targetcytokine inducible SH2-containing protein, BACTS2 and CIS and CIS-1 and G18 and SOCS, CISH and IDBG-37175 and ENSG00000114737 and 1154, protein binding, Plasma membranes, Cish and IDBG-197065 and ENSMUSG00000032578 and 12700, CISH and IDBG-645783 and ENSBTAG00000022622 and 616753
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Gene info
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Identity
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Gene
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Long gene namecytokine inducible SH2 containing protein
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Synonyms gene name
- cytokine inducible SH2-containing protein
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Synonyms
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GenBank acession
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Locus
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Discovery year1996-09-23
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Suppressors of cytokine signaling
- SH2 domain containing
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VEGA ID
MeSH Data
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Name
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ConceptScope note: A technique for visualizing CHROMOSOME ABERRATIONS using fluorescently labeled DNA probes which are hybridized to chromosomal DNA. Multiple fluorochromes may be attached to the probes. Upon hybridization, this produces a multicolored, or painted, effect with a unique color at each site of hybridization. This technique may also be used to identify cross-species homology by labeling probes from one species for hybridization with chromosomes from another species.
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Tree numbers
- E01.370.225.500.620.670.325.350.125
- E01.370.225.750.600.670.325.350.125
- E05.200.500.620.670.325.350.125
- E05.200.750.600.670.325.350.125
- E05.393.285.350.125
- E05.393.661.475.350.125
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data