Rabbit Anti Human ARHGEF18 Antibody-HRP

• Catalog number
  CSB-PA05275B0Rb_50ug
• Price
  Please ask
• Size
  50ug

• Long name
  Rabbit Antibody against Human ARHGEF18, HRP
• Synonym name
  ARHGEF18 Human Antibody
• Species reactivity
  Human
• Tested applications recommended dilutions
  ELISA
• Conjugation
  HRP
• Antibody isotype
  IgG
• UniProt ID
  Q6ZSZ5
• Format
  Liquid, diluted in buffer
• Buffer composition
  Preservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Purity
  >95%
• Purification method
  Protein G purified
• Antibody category
  Polyclonal Antibodies
• Immunogen type
  Recombinant human Rho guanine nucleotide exchange factor 18 protein (159-551AA)
• Immunogen species
  Human
• Alias
  ARHGEF18
• Background
  Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). p114RgoGEF cts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. It may play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS), but does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production.
• Clonality
  Polyclonal antibody
• Shipping and storage
  ARHGEF18 Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
• Short name of the antigen
  Rho guanine nucleotide exchange factor 18 protein
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
• Properties
  If you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. HRP conjugates are often primary rabbit polyclonal antibodies couples to the enzyme horseradish peroxidase (HRP), found in the roots of horseradish. Also monoclonal HRP conjugates are often used for Western Blot. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Additional conjugation
  HRP Conjugated
• About
  Rabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Latin name
  Oryctolagus cuniculus
• French translation
  anticorps

• Gene target
  ARHGEF18  
• Gene symbol
  ARHGEF18-AS1, ARHGEF18
• Short name
  Anti-ARHGEF18
• Technique
  anti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for
• Host
  Rabbit, Rabbits
• Label
  HRP
• Species
  Human, Humans
• Alternative name
  ARHGEF18 Antibody,HRP conjugated
• Alternative technique
  antibodies, rabbit-anti
• Alternative to gene target
  Rho/Rac guanine nucleotide exchange factor (GEF) 18, ARHGEF18 and IDBG-22691 and ENSG00000104880 and 23370, Rho guanyl-nucleotide exchange factor activity, Cell surfaces

Gene info

• Identity
  HGNC:55284
• Gene
  ARHGEF18-AS1
• Long gene name
  ARHGEF18 antisense RNA 1
• Locus
  19p13.2
• Discovery year
  2020-10-14
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:17090
• Gene
  ARHGEF18
• Long gene name
  Rho/Rac guanine nucleotide exchange factor 18
• Synonyms gene name
  • rho/rac guanine nucleotide exchange factor (GEF) 18
  • Rho/Rac guanine nucleotide exchange factor (GEF) 18
• Synonyms
  • P114-RhoGEF
  • KIAA0521
  • MGC15913
  • p114RhoGEF
• Synonyms name
  • Rho-specific guanine nucleotide exchange factor p114
• GenBank acession
  • AK074372
• Locus
  19p13.2
• Discovery year
  2004-01-09
• Entrez gene record
  23370
• Pubmed identfication
  • 9628581
  • 11318610
• RefSeq identity
  • NM_015318
• Classification
  • Dbl family Rho GEFs
  • Pleckstrin homology domain containing
• VEGA ID
  OTTHUMG00000177342

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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