Active Vitamin D Receptor (VDR)

• Catalog number
  APA475Hu01-200ug
• Price
  Please ask
• Size
  200ug

• Description
  Recombinant Human Vitamin D Receptor expressed in: E.coli
• Specifications
  Host species: Homo sapiens (Human); Expression system: E.coli; Expression region: Met272~Ser427; Purity: > 90%; Endotoxin level:
• Additional_information
  Uniprot ID: P11473; Buffer composition: 100mMNaHCO3, 500mMNaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.; Form: Freeze-dried powder; Predicted Molecular Mass (KD): 21.6kDa; Isoelectric Point: 6.5
• Storage_and_shipping
  Shipped on ice packs. Upon receipt keep at 2-8 °C for up to 1 month. For long term storage prepare working aliquots and keep frozen at -20 or -80 °C. Avoid repeated freezing and thawing.
• Notes
  Research Use Only.
• Additional description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

• Gene target
  Active   Vitamin   Receptor   VDR  
• Gene symbol
  VDR
• Short name
  Active Vitamin D Receptor (VDR)
• Alternative name
  functionnal Vitamin D Receptor (vitamin D (1,25- dihydroxyvitamin D3) receptor)
• Alternative to gene target
  vitamin D (1,25- dihydroxyvitamin D3) receptor, NR1I1 and PPP1R163, VDR and IDBG-29237 and ENSG00000111424 and 7421, lithocholic acid binding, nuclei, Vdr and IDBG-179227 and ENSMUSG00000022479 and 22337, VDR and IDBG-633008 and ENSBTAG00000016414 and 533656

Gene info

• Identity
  HGNC:12679
• Gene
  VDR
• Long gene name
  vitamin D receptor
• Synonyms gene name
  • vitamin D (1,25- dihydroxyvitamin D3) receptor
• Synonyms
  • NR1I1
  • PPP1R163
• Synonyms name
  • protein phosphatase 1, regulatory subunit 163
  • 1,25- dihydroxyvitamin D3 receptor
• GenBank acession
  • J03258
• Locus
  12q13.11
• Discovery year
  1989-06-30
• Entrez gene record
  7421
• Pubmed identfication
  • 1662663
• Classification
  • Protein phosphatase 1 regulatory subunits
  • Nuclear receptor subfamily 1 group I
• VEGA ID
  OTTHUMG00000169890
• Locus Specific Databases
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database

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