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Target antigen
Wnt3
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
mouse, rat
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Analyses
WB
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Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human Wnt3 (185-207aa AMNKHNNEAGRTTILDHMHLKCK), identical to the related mouse sequence.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the Wnt3 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The Wnt3 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.
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Related articles
1. "Entrez Gene: WNT3 wingless-type MMTV integration site family, member 3". 2. Liu P, Wakamiya M, Shea MJ et al. (1999). "Requirement for Wnt3 in vertebrate axis formation".Nat. Genet. 22 (4): 361–5. 3. Roelink H, Wang J, Black DM, Solomon E, Nusse R (Dec 1993). "Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene". Genomics 17 (3): 790–2.
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Gene Name
WNT3
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Protein Name
Proto-oncogene Wnt-3
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Gene Full Name
wingless-type MMTV integration site family, member 3
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Synonyms
Int 4 antibody|INT4 antibody|MGC131950 antibody|MGC138321 antibody|MGC138323 antibody|Proto-oncogene Int-4 homolog antibody|Proto-oncogene Wnt-3 antibody|wingless type MMTV integration site family member 3 antibody|Wnt 3 proto oncogene protein antibody|WNT 3 proto oncogene protein precursor antibody|wnt3 antibody|WNT3_HUMAN antibody
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Uniprot ID
P56703
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Entrez GeneID
7473
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
