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Target antigen
Unrip
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, mouse
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Analyses
WB,IHC-P
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Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Unrip(78-104aa AADFTAKVWDAVSGDELMTLAHKHIVK), identical to the related mouse and rat sequences.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the Unrip Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The Unrip Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
Unrip is also known as STRAP(Serine-threonine kinase receptor-associated protein). It is anenzyme that in humans is encoded by the STRAP gene. It is mapped to 12p12.3. UNRIP is integrated into a complex with UNR or with the SMN complex in vivo in a mutually exclusive manner. It is concluded that UNRIP is the first component of the uridine-rich snRNP assembly machinery that associates with the SMN complex in a compartment-specific way, and it may play a crucial role in the intracellular distribution of the SMN complex.
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Related articles
1. Datta PK, Chytil A, Gorska AE, Moses HL (December 1998). "Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling". J. Biol. Chem. 273 (52): 34671–4. 2. Grimmler, M., Otter, S., Peter, C., Muller, F., Chari, A., Fischer, U. Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization. Hum. Molec. Genet. 14: 3099-3111, 2005.
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Gene Name
STRAP
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Protein Name
Serine-threonine kinase receptor-associated protein
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Gene Full Name
serine/threonine kinase receptor associated protein
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Synonyms
MAP activator with WD repeats antibody|MAWD antibody|PT-WD antibody|PTWD antibody|Serine-threonine kinase receptor-associated protein antibody|serine/threonine kinase receptor associated protein antibody|STRAP antibody|STRAP_HUMAN antibody|unr interacting protein antibody|unr-interacting protein antibody|UNRIP antibody|WD 40 repeat protein PT WD antibody|WD-40 repeat protein PT-WD antibody
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Uniprot ID
Q9Y3F4
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Entrez GeneID
11171
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
