Unrip Antibody

• Catalog number
  bs-5132R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Unrip Primary Polyclonal Antibody
• Also known as
  Unrip PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Unrip
• Specificity
  This is a highly specific antibody against Unrip.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Unrip
• Gene ID number
  11171
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Unrip is part of the SMN complex that plays a role in snRNP assembly in the cytoplasm and pre mRNA splicing in the nucleus. Unrip interacts directly with Gemin 6 and Gemin 7 in the SMN complex. It is associated with the complex in the cytoplasm but not in the nucleus and thus is thought to play a role in it's subcellular localisation.It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  MAP activator with WD repeats; MAWD; PTWD; serine/threonine kinase receptor associated protein; STRAP; UNR-interacting protein; UNRIP; WD 40 repeat protein PT WD; STRAP_HUMAN.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Unrip  
• Gene symbol
  STRAP
• Short name
  Anti-Unrip
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Unrip Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:30796
• Gene
  STRAP
• Long gene name
  serine/threonine kinase receptor associated protein
• Synonyms
  • UNRIP
  • pt-wd
  • MAWD
• Synonyms name
  • Unr-interacting protein
  • mitogen-activated protein kinase activator with WD repeats
  • MAPK activator with WD repeats
• GenBank acession
  • AB024327
• Locus
  12p12.3
• Discovery year
  2004-04-19
• Entrez gene record
  11171
• RefSeq identity
  • NM_007178
• Classification
  • SMN complex
  • WD repeat domain containing
• VEGA ID
  OTTHUMG00000168791

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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