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Target antigen
Tec
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, rat Predicted to work with: mouse
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Analyses
WB,IHC-P
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Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Tec(612-631aa FEDLLRTIDELVECEETFGR), identical to the related rat sequence, and different from the related mouse sequence by one amino acid.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the Tec Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The Tec Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
TEC(TEC Protein Tyrosine Kinase), is an enzyme that in humans is encoded by the TEC gene. The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. By fluorescence in situ hybridization, Sato et al.(1994) mapped the gene to 4p12, the same location reported for TXK. Mouse Tec is a non-receptor type protein-tyrosine kinase that is highly expressed in many hematopoietic cell lines. Hantschel et al.(2007) identified TEC kinase and BTK kinase as major binders of the tyrosine kinase inhibitor dasatinib, which is used for treatment of BCR/ABL-positive CML.
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Related articles
1. Hantschel, O., Rix, U., Schmidt, U., Burckstummer, T., Kneidinger, M., Schutze, G., Colinge, J., Bennett, K. L., Ellmeier, W., Valent, P., Superti-Furga, G. The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib. Proc. Nat. Acad. Sci. 104: 13283-13288, 2007. 2. Sato, K., Mano, H., Ariyama, T., Inazawa, J., Yazaki, Y., Hirai, H. Molecular cloning and analysis of the human Tec protein-tyrosine kinase. Leukemia 8: 1663-1672, 1994.
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Gene Name
TEC
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Protein Name
Tyrosine-protein kinase Tec
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Gene Full Name
tec protein tyrosine kinase
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Synonyms
MGC126760 antibody|MGC126762 antibody|PSCTK4 antibody|Tec antibody|Tec protein tyrosine kinase antibody|TEC_HUMAN antibody|Tyrosine protein kinase antibody|Tyrosine-protein kinase Tec antibody
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Uniprot ID
P42680
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
