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Target antigen
Periostin
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human Predicted to work with: mouse, rat
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Analyses
WB
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Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of mouse Periostin(24-41aa NSYYDKVLAHSRIRGRDQ), identical to the related rat sequence, and different from the related human sequence by three amino acids.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the Periostin Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The Periostin Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
POSTN(Periostin), also known as PN or OSF2, is a protein that in humans is encoded by the POSTN gene. The International Radiation Hybrid Mapping Consortium mapped the POSTN gene to chromosome 13. Gillan et al.(2002) found that purified recombinant PN supported adhesion of ovarian epithelial cells. Shao et al.(2004) found that periostin was overexpressed by the majority of human primary breast cancers examined. Transfected tumor cell lines overexpressing periostin showed accelerated growth and angiogenesis as xenografts in immunocompromised animals. Kuhn et al.(2007) showed that extracellular periostin induced reentry of differentiated mammalian cardiomyocytes into the cell cycle.
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Related articles
1. Gillan, L., Matei, D., Fishman, D. A., Gerbin, C. S., Karlan, B. Y., Chang, D. D. Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha-V-beta-3 and alpha-V-beta-5 integrins and promotes cell motility. Cancer Res. 62: 5358-5364, 2002. 2. Kuhn, B., del Monte, F., Hajjar, R. J., Chang, Y.-S., Lebeche, D., Arab, S., Keating, M. T. Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nature Med. 13: 962-969, 2007. 3. Shao, R., Bao, S., Bai, X., Blanchette, C., Anderson, R. M., Dang, T., Gishizky, M. L., Marks, J. R., Wang, X.-F. Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. Molec. Cell. Biol. 24: 3992-4003, 2004.
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Gene Name
POSTN
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Protein Name
Periostin
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Gene Full Name
periostin, osteoblast specific factor
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Synonyms
MGC119510 antibody|MGC119511 antibody|OSF 2 antibody|OSF-2 antibody|OSF2 antibody|Osteoblast specific factor 2(fasciclin I like) antibody|osteoblast specific factor 2(fasciclin I-like) antibody|Osteoblast specific factor 2 antibody|Osteoblast specific factor antibody|Osteoblast-specific factor 2 antibody|PDLPOSTN antibody|Periodontal ligament specific periostin antibody|Periostin antibody|Periostin isoform thy2 antibody|Periostin isoform thy4 antibody|Periostin isoform thy6 antibody|Periostin isoform thy8 antibody|Periostin osteoblast specific factor antibody|PN antibody|POSTN antibody|POSTN_HUMAN antibody|RP11 412K4.1 antibody
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Uniprot ID
Q62009
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps