NRG1 Antibody

• Catalog number
  F49507-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  NRG1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, FACS, IHC, ELISA
• Recommended dilutions
  Western blot: 1:1000,Flow Cytometry: 1:10-1:50,IHC (Paraffin): 1:50-1:100
• Notes
  Titration of the NRG1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This NRG1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q02297
• Purity
  Purified
• Description
  Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.
• Immunogen
  A portion of amino acids 198-229 from the human protein was used as the immunogen for this NRG1 antibody.
• Storage
  Aliquot the NRG1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  NRG1  
• Gene symbol
  NRG1-IT1, NRG1, NRG1-IT3
• Short name
  Anti-NRG1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to NRG1
• Alternative technique
  antibodies
• Alternative to gene target
  neuregulin 1, ARIA and GGF and GGF2 and HGL and HRG and HRG1 and HRGA and MST131 and MSTP131 and NDF and NRG1-IT2 and SMDF, NRG1 and IDBG-16182 and ENSG00000157168 and 3084, ErbB-3 class receptor binding, nuclei, Nrg1 and IDBG-146861 and ENSMUSG00000062991 and 211323, NRG1 and IDBG-628923 and ENSBTAG00000004150 and 281361

Gene info

• Identity
  HGNC:43633
• Gene
  NRG1-IT1
• Long gene name
  NRG1 intronic transcript 1
• Synonyms gene name
  • NRG1 intronic transcript 1 (non-protein coding)
• GenBank acession
  • BC037250
• Locus
  8p12
• Discovery year
  2011-12-06
• Classification
  • Intronic transcripts
• VEGA ID
  OTTHUMG00000163966

Gene info

• Identity
  HGNC:7997
• Gene
  NRG1
• Long gene name
  neuregulin 1
• Synonyms gene
  • HGL
  • NRG1-IT2
• Synonyms gene name
  • NRG1 intronic transcript 2 (non-protein coding)
• Synonyms
  • HRG
  • NDF
  • GGF
• GenBank acession
  • L12261
• Locus
  8p12
• Discovery year
  1999-03-19
• Entrez gene record
  3084
• Pubmed identfication
  • 1350381
  • 8095334
• Classification
  • I-set domain containing
  • Neuregulins
• VEGA ID
  OTTHUMG00000163918

Gene info

• Identity
  HGNC:43635
• Gene
  NRG1-IT3
• Long gene name
  NRG1 intronic transcript 3
• Synonyms gene name
  • NRG1 intronic transcript 3 (non-protein coding)
• Locus
  8p12
• Discovery year
  2011-12-06
• Classification
  • Intronic transcripts
• VEGA ID
  OTTHUMG00000164003

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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