Netrin 1 Antibody

• Catalog number
  PA1662
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  Netrin 1
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human Predicted to work with: mouse, rat
• Analyses
  WB
• Immunogen
  A synthetic peptide corresponding to a sequence at the N-terminus of human Netrin 1(32-51aa AGQAAQPDPCSDENGHPRRC), identical to the related rat and mouse sequences.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the Netrin 1 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The Netrin 1 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  Netrin-1(NTN1), also known as NTN1L, is a diffusible protein made by floor plate cells. Netrin-1 is found in the floor plate and neuroepithelial cells of the ventral region of the spinal cord, as well as other locations in the nervous system including the somatic mesoderm, pancreas and cardiac muscle. The human NTN1 gene is mapped to chromosome 17p13-p12 by FISH. Netrin-1 can attract spinal commissural axons and repel trochlear axons in vitro. And netrin-1 expression confers a selective advantage for tumor cell survival. The binding of netrin-1 to DCC appears to depend on the presence of a coreceptor or accessory proteins. Adenosine A2b receptor is actually a netrin-1 receptor and induces cAMP accumulation on binding netrin-1, and that netrin-1-dependent outgrowth of dorsal spinal cord axons directly involves A2b. Netrin-1 can promote intestinal tumor development, probably by regulating cell survival. Thus, a netrin-1 receptor or receptors function as conditional tumor suppressors. Expression of Unc5b triggered endothelial cell repulsion in response to netrin-1 in vitro, whereas a truncated Unc5b lacking the intracellular signaling domain failed to induce repulsion.
• Related articles
  1. Colon-Ramos, D. A., Margeta, M. A., Shen, K. Glia promote local synaptogenesis through UNC-6 (netrin) signaling in C. elegans. Science 318: 103-106, 2007. 2. Corset, V., Nguyen-Ba-Charvet, K. T., Forcet, C., Moyse, E., Chedotal, A., Mehlen, P. Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor. Nature 407: 747-750, 2000. 3. Powell AW, Sassa T, Wu Y, Tessier-Lavigne M, Polleux F (May 2008). Ghosh, Anirvan. ed. "Topography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon."
• Gene Name
  NTN1
• Protein Name
  Netrin-1
• Gene Full Name
  netrin 1
• Synonyms
  NET1_HUMAN antibody|Netrin 1, mouse, homolog of antibody|Netrin 1-like antibody|Netrin-1 antibody|Netrin1 antibody|Ntn 1 antibody|NTN 1L antibody|Ntn1 antibody|NTN1L antibody|Unc6 antibody
• Uniprot ID
  O95631
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Netrin  
• Gene symbol
  NTN1, DCC, WFIKKN1
• Short name
  Netrin 1 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  Netrin 1 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:8029
• Gene
  NTN1
• Long gene name
  netrin 1
• Synonyms
  • NTN1L
• Synonyms name
  • Netrin-1
• GenBank acession
  • U75586
• Locus
  17p13.1
• Discovery year
  1999-04-15
• Entrez gene record
  9423
• Pubmed identfication
  • 9950216
• Classification
  • Netrins
• VEGA ID
  OTTHUMG00000130257

Gene info

• Identity
  HGNC:2701
• Gene
  DCC
• Long gene name
  DCC netrin 1 receptor
• Synonyms gene name
  • deleted in colorectal carcinoma
• Synonyms
  • IGDCC1
  • NTN1R1
• Synonyms name
  • immunoglobulin superfamily, DCC subclass, member 1
• GenBank acession
  • X76132
• Locus
  18q21.2
• Discovery year
  1990-05-25
• Entrez gene record
  1630
• Pubmed identfication
  • 2294591
  • 24400119
• RefSeq identity
  • NM_005215
• Classification
  • Fibronectin type III domain containing
  • MicroRNA protein coding host genes
  • I-set domain containing
• VEGA ID
  OTTHUMG00000132698
• Locus Specific Databases
  • LRG_1107

Gene info

• Identity
  HGNC:30912
• Gene
  WFIKKN1
• Long gene name
  WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
• Synonyms gene
  • C16orf12
• Synonyms gene name
  • chromosome 16 open reading frame 12
• Synonyms
  • RJD2
  • WFIKKN
  • WFDC20A
• Synonyms name
  • WAP four-disulfide core domain 20A
• GenBank acession
  • AK075356
• Locus
  16p13.3
• Discovery year
  2004-08-24
• Entrez gene record
  117166
• Pubmed identfication
  • 11274388
  • 11928817
• RefSeq identity
  • NM_053284
• Classification
  • WAP four-disulfide core domain containing
  • I-set domain containing
• VEGA ID
  OTTHUMG00000090359

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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