Rabbit anti Netrin 1

• Catalog number
  X1870P
• Price
  Please ask
• Size
  25 μg

• Category
  Primary Antibodies
• Long description
  Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis._x000B__x000B_Netrin 1Õs main receptor is DCC (deleted in colorectal cancer- a putative tumor suppressor gene whose expression is lost in numerous cancers). DCC belongs to the so-called family of dependence receptors. These receptors induce apoptosis when their ligand is absent, thus conferring a state of cellular dependence on Netrin 1 availability. The DCC/netrin-1 duo regulates neuron survival during nervous system development. The mechanism(s) by which Netrin 1/ DCC triggers cell death are still unknown. The localization of DCC to lipid rafts appears to be a prerequisite for its proapoptotic activity.
• Antibody come from
  Synthetic peptide derived from the N-terminal region of the amyloid beta peptide.
• Other description
  Purified IgG in phosphate buffered saline, pH 7.4. Antigen Immunoaffiinity Purification
• Clone
  Polyclonal
• Antigen antibody binding interaction
  Rabbit anti Netrin 1 Antibody
• Antibody is raised in
  Rabbit
• Antibody s reacts with
  Human, Mouse, Rat, Cow, Macaque, Cat
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  No Data Available
• Application
  Western Blot
• Antibody s suited for
  For dot blot applications, we recommend using the antibody at 1.0 µg/mL.Optimal concentration should be evaluated by serial dilutions.
• Storage
  -80ºC
• Relevant references
  1. Head, E., Moffat, K., Das, P., Sarsoza, F., Poon, W.W., Landsberg, G., Cotman, C.W., Murphy, M.P. (2005) -Amyloid deposition and tau phosphorylation in clinically characterized aged cats. Neurobiol Aging. 26(5): 749-763._x000B__x000B_2. Borchelt, D.R. et al. (1997) Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19:939-945. _x000B__x000B_3. Savage, M.J. et al. (1998) Turnover of amyloid -protein in mouse brain and acute reduction of its level by phorbol ester. J. Neurosci. 18:1743-1752.
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• About
  Rabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Latin name
  Oryctolagus cuniculus

• Gene target
  Netrin  
• Gene symbol
  NTN1, DCC, WFIKKN1
• Short name
  Rabbit anti Netrin 1
• Technique
  Rabbit, anti, antibody to
• Host
  Rabbit, Rabbits
• Isotype
  not specified
• Label
  unlabeled
• Alternative name
  production species: rabbit antibody to Netrin 1
• Alternative technique
  rabbit-anti, antibodies

Gene info

• Identity
  HGNC:8029
• Gene
  NTN1
• Long gene name
  netrin 1
• Synonyms
  • NTN1L
• Synonyms name
  • Netrin-1
• GenBank acession
  • U75586
• Locus
  17p13.1
• Discovery year
  1999-04-15
• Entrez gene record
  9423
• Pubmed identfication
  • 9950216
• Classification
  • Netrins
• VEGA ID
  OTTHUMG00000130257

Gene info

• Identity
  HGNC:2701
• Gene
  DCC
• Long gene name
  DCC netrin 1 receptor
• Synonyms gene name
  • deleted in colorectal carcinoma
• Synonyms
  • IGDCC1
  • NTN1R1
• Synonyms name
  • immunoglobulin superfamily, DCC subclass, member 1
• GenBank acession
  • X76132
• Locus
  18q21.2
• Discovery year
  1990-05-25
• Entrez gene record
  1630
• Pubmed identfication
  • 2294591
  • 24400119
• RefSeq identity
  • NM_005215
• Classification
  • Fibronectin type III domain containing
  • MicroRNA protein coding host genes
  • I-set domain containing
• VEGA ID
  OTTHUMG00000132698
• Locus Specific Databases
  • LRG_1107

Gene info

• Identity
  HGNC:30912
• Gene
  WFIKKN1
• Long gene name
  WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
• Synonyms gene
  • C16orf12
• Synonyms gene name
  • chromosome 16 open reading frame 12
• Synonyms
  • RJD2
  • WFIKKN
  • WFDC20A
• Synonyms name
  • WAP four-disulfide core domain 20A
• GenBank acession
  • AK075356
• Locus
  16p13.3
• Discovery year
  2004-08-24
• Entrez gene record
  117166
• Pubmed identfication
  • 11274388
  • 11928817
• RefSeq identity
  • NM_053284
• Classification
  • WAP four-disulfide core domain containing
  • I-set domain containing
• VEGA ID
  OTTHUMG00000090359

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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