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Target antigen
CCR6
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
Human, Mouse, Rat. No cross reactivity with other proteins.
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Analyses
WB
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Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human CCR6(358-374aa RQTSETADNDNASSFTM), different from the related rat and mouse sequences by two amino acids.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the CCR6 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The CCR6 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
CCR6, also termed CKRL3, encodes a 369-amino acid polypeptide with greatest similarity to the family of alpha-chemokine-binding receptors. Unlike most chemokine receptor genes, it is encoded by more than 1 exon. Weakly expressed as a 4-kb transcript in spleen, lymph nodes, peripheral blood lymphocytes and appendix, CCR6 gene is located at 6q27. As the receptor for MIP-3-alpha, its activation leads to phospholipase C-dependent intracellular Ca(2+) mobilization. Additionally, CCR6 are markedly upregulated in psoriasis.
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Related articles
1. Zaballos, A.; Varona, R.; Gutierrez, J.; Lind, P.; Marquez, G. : Molecular cloning and RNA expression of two new human chemokine receptor-like genes. Biochem. Biophys. Res. Commun. 227: 846-853, 1996. 2. Liao, F.; Lee, H.-H.; Farber, J. M. : Cloning of STRL22, a new human gene encoding a G-Protein-coupled receptor related to chemokine receptors and located on chromosome 6q27. Genomics 40: 175-180, 1997. 3. Homey, B.; Dieu-Nosjean, M.-C.; Wiesenborn, A.; Massacrier, C.; Pin, J.-J.; Oldham, E.; Catron, D.; Buchanan, M. E.; Muller, A.; de Waal Malefyt, R.; Deng, G.; Orozco, R.; Ruzicka, T.; Lehmann, P.; Lebecque, S.; Caux, C.; Zlotnik, A. : Up-regulation of macrophage inflammatory protein-3-alpha/CCL20 and CC chemokine receptor 6 in psoriasis. J. Immun. 164: 6621-6632, 2000.
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Gene Name
CCR6
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Protein Name
C-C chemokine receptor type 6(C-C CKR-6/CC-CKR-6/CCR-6)
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Gene Full Name
chemokine(C-C motif) receptor 6
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Synonyms
BN 1 antibody|BN1 antibody|C C chemokine receptor type 6 antibody|C C CKR 6 antibody|C-C chemokine receptor type 6 antibody|C-C CKR-6 antibody|CC chemokine receptor type 6 antibody|CC CKR 6 antibody|CC R6 antibody|CC-CKR-6 antibody|CCCKR6 antibody|CCR 6 antibody|CCR-6 antibody|Ccr6 antibody|CCR6_HUMAN antibody|CD 196 antibody|CD196 antibody|CD196 antigen antibody|Chemokine(C C motif) receptor 6 antibody|Chemokine(C C) receptor 6 antibody|Chemokine(CC motif) receptor 6 antibody|Chemokine(CC) receptor 6 antibody|Chemokine receptor 6 antibody|Chemokine receptor like 3 antibody|Chemokine receptor-like 3 antibody|CKR 6 antibody|CKR L3 antibody|CKR-L3 antibody|CKR6 antibody|CKRL3 antibody|CMKBR6 antibody|CMKBR6 antibody|DCR 2 antibody|DCR2 antibody|DRY 6 antibody|DRY6 antibody|G protein coupled receptor 29 antibody|G-protein coupled receptor 29 antibody|GPR 29 antibody|GPR CY4 antibody|GPR-CY4 antibody|GPR29 antibody|GPRCY 4 antibody|GPRCY4 antibody|LARC receptor antibody|Seven transmembrane receptor lymphocyte 22 antibody|STRL 22 antibody|STRL22 antibody
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Uniprot ID
P51684
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
