ABCB11 Antibody

• Catalog number
  PA1393
• Price
  Please ask
• Size
  0,1 mg

• Target antigen
  ABCB11
• Clonality
  Polyclonal antibody
• Clone
  Polyclonal antibody
• Raised in
  rabbit
• Type of the antibody
  IgG polyclonal antibody
• Product form
  freeze-dried
• Reacts with species
  human, mouse, rat
• Analyses
  WB,IHC-P
• Immunogen
  A synthetic peptide corresponding to a sequence at the C-terminus of human ABCB11(1299-1313aa THEELMAQKGAYYKL), different from the related rat sequence by one amino acid, and from the mouse sequence by three amino acids.
• Product configuration
  Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Purification
  Immunogen affinity purified.
• Solubilization
  The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
• Storage condtions
  Keep the ABCB11 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
• Tips
  The ABCB11 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
• Background
  Bile Salt Export Pump(BSEP) is a protein which in humans is encoded by the ABCB11 gene. It is a member of the superfamily of ATP-binding cassette(ABC) transporters, also known as ABCB11. It is mapped to chromosome 2q24. The BSEP protein is mainly expressed in the liver. ABCB11 is a gene associated with progressive familial intrahepatic cholestasis type 2(PFIC2) which caused by mutations in the ABCB11 gene will increases the risk of hepatocellular carcinoma in early life.
• Related articles
  1. Strautnieks SS, Bull LN, Knisely AS, Kocoshis SA, Dahl N, Arnell H, Sokal E, Dahan K, Childs S, Ling V, Tanner MS, Kagalwalla AF, Németh A, Pawlowska J, Baker A, Mieli-Vergani G, Freimer NB, Gardiner RM, Thompson RJ (November 1998). "A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis". Nat. Genet. 20 (3): 233–8. 2. Strautnieks, S., Kagalwalla, A. F., Tanner, M. S., Knisely, A. S., Bull, L. N., Freimer, N. B., Kocoshis, S. A., Gardiner, R. M., Thompson, R. J.Identification of a second locus for progressive familial intrahepatic cholestasis on chromosome 2q24.Medizinische Genetik9: 16-only, 1997. 3. Noe J, Kullak-Ublick GA, Jochum W, Stieger B, Kerb R, Haberl M, Müllhaupt B, Meier PJ, Pauli-Magnus C (September 2005). "Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis". J. Hepatol. 43 (3): 536–43. 4. Knisely AS, Strautnieks SS, Meier Y, Stieger B, Byrne JA, Portmann BC, Bull LN, Pawlikowska L, Bilezikçi B, Ozçay F, László A, Tiszlavicz L, Moore L, Raftos J, Arnell H, Fischler B, Németh A, Papadogiannakis N, Cielecka-Kuszyk J, Jankowska I, Pawłowska J, Melín-Aldana H, Emerick KM, Whitington PF, Mieli-Vergani G, Thompson RJ (August 2006). "Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency". Hepatology 44 (2): 478–86.
• Gene Name
  ABCB11
• Protein Name
  Bile salt export pump
• Gene Full Name
  ATP-binding cassette, sub-family B(MDR/TAP), member 11
• Synonyms
  ABC member 16, MDR/TAP subfamily antibody|ABCB1 antibody|Abcb11 antibody|ABCBB_HUMAN antibody|ATP binding cassette sub family B(MDR/TAP) member 11 antibody|ATP binding cassette sub family B member 11 antibody|ATP-binding cassette sub-family B member 11 antibody|Bile salt export pump antibody|BRIC2 antibody|Bsep antibody|PGY4 antibody|progressive familial intrahepatic cholestasis 2 antibody|Sister of P glycoprotein antibody|Spgp antibody
• Uniprot ID
  O95342
• Properties
  If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ABCB11  
• Gene symbol
  ABCB11
• Short name
  ABCB11 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  ABCB11 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:42
• Gene
  ABCB11
• Long gene name
  ATP binding cassette subfamily B member 11
• Synonyms gene
  • BSEP
  • PFIC2
• Synonyms gene name
  • progressive familial intrahepatic cholestasis 2
  • bile salt export pump
  • ATP-binding cassette, sub-family B (MDR/TAP), member 11
• Synonyms
  • ABC16
  • SPGP
  • PFIC-2
  • PGY4
• Synonyms name
  • ABC member 16, MDR/TAP subfamily
• GenBank acession
  • AF091582
• Locus
  2q31.1
• Discovery year
  1998-09-25
• Entrez gene record
  8647
• Pubmed identfication
  • 9806540
• RefSeq identity
  • NM_003742
• Classification
  • ATP binding cassette subfamily B
• VEGA ID
  OTTHUMG00000154039
• Locus Specific Databases
  • CCHMC-BMI & UC Hearing Loss Mutation Database
  • LRG_1199

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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