Recombinant Mouse ICOS Ligand/B7-H2/CD275 (C-6His)

Alternative names

B7 homolog 2; B7-H2;B7-like protein Gl50; B7RP-1LICOS; CD275; CD275 antigen; ICOS ligand; ICOSL; ICOS-L;inducible T-cell co-stimulator ligand; B7RP-1; CD275; GL50; ICOSL; ICOSLG; B7H2;B7RP1
Description

Recombinant Mouse ICOS Ligand is produced by our Mammalian expression system and the target gene encoding Glu47-Lys279 is expressed fused with a 6His tag at the C-terminus.
Expression

Human Cells
Tag

C-His
Endotoxin

Less than 0.1 ng/ug (1 EU/ug)
Accession

Q9JHJ8
TargetSequence

Glu47-Lys279
Shipping

Ambient
Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Note

For research use only.
Additional description

FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
Test

Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
Latin name

Mus musculus
Source

Recombinants or rec. proteins
Group

recombinants

Gene target

ICOS Ligand/B7-H2/CD275 C-6His
Gene symbol

ICOSLG, NCAPH2, ICOS, TUBA3D, HHLA2, RNY4P2, LRRC23, NME2, PCDHGB7, CFB
Short name

Recombinant Mouse ICOS Ligand/B7-H2/CD275 (C-6His)
Technique

Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Bon Opus advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
Host

mouse
Species

Mouse, Mouses
Alternative name

Rec. Mouse inducible T-cell co-stimulator Ligand/B7-H2/CD275 (C-6His)
Alternative technique

rec, murine
Alternative to gene target

inducible T-cell co-stimulator, ICOS and IDBG-79246 and ENSG00000163600 and 29851, protein binding, Extracellular, Icos and IDBG-159737 and ENSMUSG00000026009 and 54167, ICOS and IDBG-643378 and ENSBTAG00000021596 and 507026

Identity

HGNC:5351
Gene

ICOS
Long gene name

inducible T cell costimulator
Synonyms gene name
- inducible T-cell costimulator
Synonyms
- AILIM
- CD278
Synonyms name
- activation-inducible lymphocyte immunomediatory molecule
GenBank acession
- AB023135
Locus

2q33.2
Discovery year

2000-02-29
Entrez gene record

29851
Pubmed identfication
- 9930702
- 10617205
RefSeq identity
- NM_012092
Classification
- CD molecules
VEGA ID

OTTHUMG00000132880
Locus Specific Databases
- ICOSbase: Mutation registry for ICOS deficiency
- LRG_65

Identity

HGNC:10246
Gene

RNY4P2
Long gene name

RNY4 pseudogene 2
Synonyms gene name
- RNA, Y4 small cytoplasmic (associated with Ro protein) pseudogene 2
- RNA, Ro-associated Y4 pseudogene 2
Synonyms
- hY4.B7
GenBank acession
- M77130
Locus

17q21.31
Discovery year

1993-08-25
Entrez gene record

6088
RefSeq identity
- NG_005037

Identity

HGNC:1037
Gene

CFB
Long gene name

complement factor B
Synonyms gene
- BFD
- BF
Synonyms gene name
- B-factor, properdin
Synonyms
- H2-Bf
GenBank acession
- L15702
Locus

6p21.33
Discovery year

1986-01-01
Entrez gene record

629
RefSeq identity
- NM_001710
Classification
- Complement system activation components
- Sushi domain containing
VEGA ID

OTTHUMG00000031198
Locus Specific Databases
- LRG_136

Name

Primary Cell Culture
Concept

Scope note: The initial culturing of cells derived directly from fresh TISSUES.
Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
Qualifiers

ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data