YM201636
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Catalog number2045-5
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PricePlease ask
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Size5 mg
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Alternative_name6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3′2′:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine carboxamide
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DescriptionCell-permeable. YM-201636 is a selective inhibitor of phosphoinositide kinase (PIK) PIKfyve (IC50 = 33 nM). It inhibits p110α at higher concentration (IC50 = 3 µM). It reversibly impairs endosomal trafficking in NIH3T3 cells, mimicking the effect produced by depleting PIKfyve with siRNA.YM-201636 also blocks retroviral exit by budding from cells.
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CAS Number371942-69-7
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₅H₂₁N₇O₃
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Molecular Weight467.49
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Cell PermeableYes
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Purity≥98% by NMR
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SolubilitiesDMSO or EtOH
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HandlingProtect from air and light
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Tag LineA PIKfyve inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24 months
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MDL NumberMFCD16038303
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PubChem CID9956222
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SMILESC1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)NC(=O)C6=CN=C(C=C6)N
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InChiInChI=1S/C25H21N7O3/c26-19-7-6-16(14-28-19)24(33)29-17-4-1-3-15(13-17) 22-30-20-18-5-2-8-27-25(18)35-21(20)23(31-22)32-9-11-34-12-10-32/h1-8, 13-14H,9-12H2,(H2,26,28)(H,29,33)
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InChi KeyYBPIBGNBHHGLEB-UHFFFAOYSA-N
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MSDS AvailableYes
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Gene target
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Short nameYM201636
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Alternative nameYM201636
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