Toceranib

• Catalog number
  B1542-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide; PHA 291639, SU 11654
• Description
  Toceranib is a potent, cell-permeable, ATP-competitive multi-targeted receptor tyrosine kinase inhibitor that is structurally related to Sunitinib (Cat. No. 2097). It potently inhibits signaling through VEGFR, FGFR, PDGFR, and Kit. Additionally, toceranib blocks the autophosphorylation of both wild type and mutant forms of Kit in response to stem cell factor, resulting in cell death. It is active in vivo and is commonly used against solid tumors in dogs.
• CAS Number
  356068-94-5
• Structure Available
  Yes
• Molecular Formula
  C₂₂H₂₅FN₄O₂
• Molecular Weight
  396.46
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~ 4 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  An ATP-competitive multi-targeted receptor tyrosine kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  5329106
• PubChem CID Link
• SMILES
  CC1=C(NC(=C1C(=O)NCCN2CCCC2)C)C=C3C4=C(C=CC(=C4)F)NC3=O
• InChi
  InChI=1S/C22H25FN4O2/c1-13-19(12-17-16-11-15(23)5-6-18(16)26-21(17)28)25-14(2)20(13)22(29)24-7-10-27-8-3-4-9-27/h5-6,11-12,25H,3-4,7-10H2,1-2H3,(H,24,29)(H,26,28)/b17-12-
• InChi Key
  SRSGVKWWVXWSJT-ATVHPVEESA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Toceranib  
• Short name
  Toceranib
• Alternative name
  Toceranib

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