Toceranib
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Catalog numberB1542-5
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Price:
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Size5 mg
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Alternative_name5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide; PHA 291639, SU 11654
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DescriptionToceranib is a potent, cell-permeable, ATP-competitive multi-targeted receptor tyrosine kinase inhibitor that is structurally related to Sunitinib (Cat. No. 2097). It potently inhibits signaling through VEGFR, FGFR, PDGFR, and Kit. Additionally, toceranib blocks the autophosphorylation of both wild type and mutant forms of Kit in response to stem cell factor, resulting in cell death. It is active in vivo and is commonly used against solid tumors in dogs.
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CAS Number356068-94-5
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Structure AvailableYes
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Molecular FormulaC₂₂H₂₅FN₄O₂
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Molecular Weight396.46
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (~ 4 mg/ml)
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HandlingProtect from air and light
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Tag LineAn ATP-competitive multi-targeted receptor tyrosine kinase inhibitor
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Storage Condition-20°C
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Shipping ConditionGel Pack
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Shelf Life36 months
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PubChem CID5329106
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SMILESCC1=C(NC(=C1C(=O)NCCN2CCCC2)C)C=C3C4=C(C=CC(=C4)F)NC3=O
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InChiInChI=1S/C22H25FN4O2/c1-13-19(12-17-16-11-15(23)5-6-18(16)26-21(17)28)25-14(2)20(13)22(29)24-7-10-27-8-3-4-9-27/h5-6,11-12,25H,3-4,7-10H2,1-2H3,(H,24,29)(H,26,28)/b17-12-
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InChi KeySRSGVKWWVXWSJT-ATVHPVEESA-N
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MSDS AvailableYes
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Gene target
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Short nameToceranib
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Alternative nameToceranib
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