Talabostat mesylate
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Catalog numberB2061-5
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PricePlease ask
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Size5 mg
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Alternative_name(R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-ylboronic acid methanesulfonic acid ; PT-100; Val-boro-pro
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DescriptionTalabostat is a nonselective inhibitor of post-proline cleaving serine proteases. The inhibition of the highly related cytosolic serine proteases Dpp8 and Dpp9 (Dpp8/9) by Val-boroPro was recently demonstrated to trigger an immunostimulatory form of programmed cell death known as pyroptosis selectively in monocytes and macrophages. Talabostat induces powerful anti-tumor immune responses in syngeneic cancer models.
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CAS Number150080-09-4
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₀H₂₃BN₂OS
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Molecular Weight310.17
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO
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HandlingProtect from air and moisture
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Tag LineA nonselective inhibitor of post-proline cleaving serine proteases
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID11522448
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SMILESB(C1CCCN1C(=O)C(C(C)C)N)(O)O.CS(=O)(=O)O
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InChiInChI=1S/C9H19BN2O3.CH4O3S/c1-6(2)8(11)9(13)12-5-3-4-7(12)10(14)15;1-5(2,3)4/h6-8,14-15H,3-5,11H2,1-2H3;1H3,(H,2,3,4)/t7-,8-;/m0./s1
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InChi KeyOXYYOEIGQRXGPI-WSZWBAFRSA-N
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MSDS AvailableYes
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Gene target
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Short nameTalabostat mesylate
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Alternative nameTalabostat mesylate
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