Sphingosine Kinase Inhibitor, SKI-II
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Catalog number2047-25
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PricePlease ask
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Size25 mg
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Alternative_name4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
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DescriptionCell-permeable. SKI-II is selective a non-lipid sphingosine kinase (SK) inhibitor. It displays non-ATP-competitive inhibition of human recombinant GST-SK 1 with an IC50 value of 0.5 µM, with no inhibition against ERK2, PI3-kinase, or PKCα at concentrations up to 60 µM.
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CAS Number312636-16-1
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₅H₁₁ClN₂OS
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Molecular Weight302.78
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Cell PermeableYes
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Purity≥90% by NMR
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SolubilitiesDMSO (100 mM)
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HandlingProtect from air and light
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Tag LineA non-lipid pan-sphingosine kinase (SK) inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24 months
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MDL NumberMFCD00733553
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PubChem CID753704
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SMILESC1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl
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InChiInChI=1S/C15H11ClN2OS/c16-11-3-1-10(2-4-11)14-9-20-15(18-14)17-12-5-7-13 (19)8-6-12/h1-9,19H,(H,17,18)
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InChi KeyZFGXZJKLOFCECI-UHFFFAOYSA-N
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MSDS AvailableYes
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolSKI, SPINK2, CRABP2, MGST2, IBSP, APOL2, MGAT2, MBTPS1, P4HA2, XYLT2
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Short nameSphingosine Kinase Inhibitor, SKI-II
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Alternative nameSphingosine phosphorylation catalyst suppressor, v-ski sarcoma viral oncogene homolog (avian)-II
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Alternative to gene targetv-ski sarcoma viral oncogene homolog (avian), SGS and SKV, SKI and IDBG-86169 and ENSG00000157933 and 6497, repressing transcription factor binding, nuclei, Ski and IDBG-207475 and ENSMUSG00000029050 and 20481, SKI and IDBG-634866 and ENSBTAG00000038716 and 506127
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Gene info
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Identity
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Gene
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Long gene nameSKI proto-oncogene
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Synonyms gene name
- v-ski avian sarcoma viral oncogene homolog
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- SKI transcriptional corepressors
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameserine peptidase inhibitor Kazal type 2
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Synonyms gene name
- serine protease inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1993-12-01
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Serine peptidase inhibitors, Kazal type
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecellular retinoic acid binding protein 2
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Synonyms gene name
- cellular retinoic acid-binding protein 2
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Synonyms
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GenBank acession
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Locus
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Discovery year1992-11-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Fatty acid binding protein family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemicrosomal glutathione S-transferase 2
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Synonyms
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GenBank acession
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Locus
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Discovery year1997-10-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Microsomal glutathione S-transferases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameintegrin binding sialoprotein
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Synonyms
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Synonyms name
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Locus
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Discovery year1993-03-23
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Entrez gene record
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Pubmed identfication
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Classification
- SIBLING family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameapolipoprotein L2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-10-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Apolipoproteins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namealpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
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Synonyms gene name
- mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-02-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Mannosyl-glycoprotein N-acetylglucosaminyltransferases
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namemembrane bound transcription factor peptidase, site 1
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Synonyms gene name
- membrane-bound transcription factor protease, site 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-03-30
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Proprotein convertase subtilisin/kexin family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameprolyl 4-hydroxylase subunit alpha 2
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Synonyms gene name
- procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II
- prolyl 4-hydroxylase, alpha polypeptide II
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-02-23
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namexylosyltransferase 2
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Synonyms gene name
- xylosyltransferase II
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-04-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Glucosaminyl (N-acetyl) transferases/xylosyltransferases
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VEGA ID
