SMN Tudor Domain (73-173 aa) GST-tagged), Human recombinant
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Catalog number7676-50
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PricePlease ask
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Size50 ug
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SynonymsSMN Tudor Domain (1472-1613 aa) (GST-tagged), Human recombinant
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Alternative_namesGemin-1; Component of Gems 1; Survival Motor Neuron Protein
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DescriptionParticipates in RNA Splicing
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RecombinantYes
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SourceE. coli
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Purity by SDS PAGE≥90%
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AssaySDS-PAGE
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Molecular Weight42.6 kDa (73-173 aa, NT GST Tag)
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Storage Temp-80°C
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Shippingdry ice
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Shelf Life6 months
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AppearanceLiquid
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Physical form description50 mM Tris-HCl, 150 mM sodium chloride, pH 8.0, containing 20% glycerol.
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Background InformationTudor domains are small protein structural motifs of ~50 amino acids related to the “Royal family” of methyl readers, which also includes chromo, MBT, PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or with other domains and are found in many proteins that are involved in RNA metabolism, germ cell development, transposon silencing, DNA damage response, histone modification and chromatin remodeling. The tudor domains recognize symmetric methylated arginine or methylated lysine residues. The Survival of Motor Neurons (SMN) protein participates in RNA splicing. The Tudor domain of SMN recognizes and binds methylated Sm proteins, which bind small nuclear RNA. SMN is encoded in humans by two separate genes, SMN1 and SMN2, which differ by one base in exon 7. In motor neuron cells, approximately 90% of the SMN2 transcripts are spliced to exclude exon 7. The SMN2 transcripts without exon 7 are less stable than SMN1 transcripts. Consequently, defects in human SMN1 result in the death of motor neuron cells and spinal muscular atrophy, which is the leading genetic cause of infantile death. This protein product contains the tudor domain region of SMN. The sequence of this region is identical in both the SMN1 and the SMN2 genes.
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolMGST3, IGHV3-73, RNU6-73P, CPSF3, STMN1, SNRPN, OR7E26P, USH1C
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Short nameSMN Tudor Domain (73-173 aa) GST-tagged), recombinant
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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SpeciesHuman, Humans
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Alternative nameSMN Tudor Domain (73-173 aa) GST-tagged), H. sapiens Rec.
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene namemicrosomal glutathione S-transferase 3
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1997-10-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Microsomal glutathione S-transferases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameimmunoglobulin heavy variable 3-73
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GenBank acession
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Locus
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Discovery year2000-04-04
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin heavy locus at 14q32.33
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameRNA, U6 small nuclear 73, pseudogene
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Synonyms gene
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Synonyms gene name
- RNA, U6 small nuclear 73
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Locus
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Discovery year2011-08-08
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Entrez gene record
Gene info
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Identity
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Gene
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Long gene namecleavage and polyadenylation specific factor 3
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Synonyms gene name
- cleavage and polyadenylation specific factor 3, 73kD subunit
- cleavage and polyadenylation specific factor 3, 73kDa
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-05-31
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MBL fold containing DNA/RNA interacting subfamily
- Endoribonucleases
- Cleavage and polyadenylation specific factor subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namestathmin 1
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Synonyms gene
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Synonyms gene name
- chromosome 1 open reading frame 215
- stathmin 1/oncoprotein 18
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1990-12-17
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Stathmins
- MicroRNA protein coding host genes
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namesmall nuclear ribonucleoprotein polypeptide N
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Synonyms gene
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Synonyms gene name
- Prader-Willi syndrome chromosome region
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1992-08-24
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Sm spliceosomal proteins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameolfactory receptor family 7 subfamily E member 26 pseudogene
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Synonyms gene
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Synonyms gene name
- olfactory receptor, family 7, subfamily E, member 26 pseudogene
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-11-29
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Entrez gene record
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Pubmed identfication
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Classification
- Olfactory receptors, family 7
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameUSH1 protein network component harmonin
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Synonyms gene
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Synonyms gene name
- deafness, autosomal recessive 18
- Usher syndrome 1C (autosomal recessive, severe)
- Usher syndrome 1C
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1992-06-08
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- PDZ domain containing
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
