SC66
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Catalog number1870-10
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Price:
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Size10 mg
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Alternative_name(2E, 6E)-2, 6-Bis(pyridine-4ylmethylene)cyclohexanone
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DescriptionCell-permeable. An allosteic Akt inhibitor that directly facilitates Akt ubiquitination in vitro and in vivo. SC66 displays a dual inhibitory activity that directly interferes with the pleckstrin homology (PH) domain binding to PIP₃ and facilitates Akt ubiquitination. Due to its dual inhibitory activity, SC66 displays a more effective growth suppression of transformed cells that contain a high level of Akt signaling, compared with other inhibitors of PIP₃/Akt pathway.
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CAS Number871361-88-5
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₈H₁₆N₂O
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Molecular Weight276.33
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Cell PermeableYes
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Purity≥95% by HPLC
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SolubilitiesDMSO
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HandlingProtect from air and light
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Tag LineAn allosteric Akt inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24 months
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MDL NumberMFCD05025493
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PubChem CID6018993
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SMILESC1CC(=CC2=CC=NC=C2)C(=O)C(=CC3=CC=NC=C3)C1
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InChiInChI=1S/C18H16N2O/c21-18-16(12-14-4-8-19-9-5-14)2-1-3-17(18)13-15-6-10-20-11-7-15/h4-13H,1-3H2/b16-12+,17-13+
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InChi KeyCYVVJSKZRBZHAV-UNZYHPAISA-N
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MSDS AvailableYes
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Gene target
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Short nameSC66
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Alternative nameSC66
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