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Alternative_name
AC220; AC010220
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Description
Cell-permeable. A second generation FLT3 receptor tyrosine kinase inhibitor. Quizartinib displays high affinity for FLT3 in a binding assay (Kd = 1.6 nM) and is a potent inhibitor in cellular autophosphorylation assays (IC₅₀ = 1.1 nM for FLT3-ITD and 4.2 nM for wt FLT3). It inhibits the growth of human leukemia cell line MV4-11 (IC₅₀0 = 0.56 nM) which is FLT3 dependent and contains a homozygous FLT3-ITD mutation, and A375 cells (IC50 > 10,000 nM) which are not FLT3 dependent and contain an activating mutation in BRAF.
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CAS Number
950769-58-1
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₉H₃₂N₆O₄S
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Molecular Weight
560.67
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Cell Permeable
Yes
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Purity
≥99% by HPLC
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Solubilities
DMSO (~200 mg/ml)
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Handling
Protect from air and light
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Tag Line
A potent FLT3 receptor tyrosine kinase inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
24months
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MDL Number
MFCD18074524
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PubChem CID
24889392
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SMILES
CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6) SC4=N3
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InChi
InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)
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InChi Key
CVWXJKQAOSCOAB-UHFFFAOYSA-N
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MSDS Available
Yes