Quizartinib

• Catalog number
  2008-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  AC220; AC010220
• Description
  Cell-permeable. A second generation FLT3 receptor tyrosine kinase inhibitor. Quizartinib displays high affinity for FLT3 in a binding assay (Kd = 1.6 nM) and is a potent inhibitor in cellular autophosphorylation assays (IC₅₀ = 1.1 nM for FLT3-ITD and 4.2 nM for wt FLT3).  It inhibits the growth of human leukemia cell line MV4-11 (IC₅₀0 = 0.56 nM) which is FLT3 dependent and contains a homozygous FLT3-ITD mutation, and A375 cells (IC50 > 10,000 nM) which are not FLT3 dependent and contain an activating mutation in BRAF.
• CAS Number
  950769-58-1
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₉H₃₂N₆O₄S
• Molecular Weight
  560.67
• Cell Permeable
  Yes
• Purity
  ≥99% by HPLC
• Solubilities
  DMSO (~200 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent FLT3 receptor tyrosine kinase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24months
• MDL Number
  MFCD18074524
• PubChem CID
  24889392
• PubChem CID Link
• SMILES
  CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6) SC4=N3
• InChi
  InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)
• InChi Key
  CVWXJKQAOSCOAB-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Quizartinib  
• Short name
  Quizartinib
• Alternative name
  Quizartinib

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