Moexipril hydrochloride

Alternative_name

(3S)-2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid hydrochloride
Description

Moexipril is a prodrug of the long-acting angiotensin converting enzyme (ACE) inhibitor moexiprilat (IC₅₀s = 2.1 nM and 2.7 µM for moexiprilat and moexipril, respectively). In addition to its antihypertensive activity, moexipril has been identified as a phosphodiesterase 4 inhibitor (IC₅₀ = 38 µM for the PDE4B2 isoform) that increases cAMP in cells.
CAS Number

82586-52-5
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₇H₃₅N₂O₇Cl
Molecular Weight

535.03
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

H₂O (30 mg/ml)
Handling

Protect from air and moisture
Tag Line

A potent angiotensin converting-Enzyme (ACE) inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD00940481
PubChem CID

54889
PubChem CID Link
SMILES

CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3=CC(=C(C=C3CC2C(=O)O)OC)OC.Cl
InChi

InChI=1S/C27H34N2O7.ClH/c1-5-36-27(33)21(12-11-18-9-7-6-8-10-18)28-17(2)25(30)29-16-20-15-24(35-4)23(34-3)14-19(20)13-22(29)26(31)32;/h6-10,14-15,17,21-22,28H,5,11-13,16H2,1-4H3,(H,31,32);1H/t17-,21-,22-;/m0./s1
InChi Key

JXRAXHBVZQZSIC-JKVLGAQCSA-N
Data Sheet Link
MSDS Available

Yes