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Alternative_name
(3S)-2-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid hydrochloride
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Description
Moexipril is a prodrug of the long-acting angiotensin converting enzyme (ACE) inhibitor moexiprilat (IC₅₀s = 2.1 nM and 2.7 µM for moexiprilat and moexipril, respectively). In addition to its antihypertensive activity, moexipril has been identified as a phosphodiesterase 4 inhibitor (IC₅₀ = 38 µM for the PDE4B2 isoform) that increases cAMP in cells.
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CAS Number
82586-52-5
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₇H₃₅N₂O₇Cl
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Molecular Weight
535.03
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
H₂O (30 mg/ml)
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Handling
Protect from air and moisture
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Tag Line
A potent angiotensin converting-Enzyme (ACE) inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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MDL Number
MFCD00940481
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PubChem CID
54889
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SMILES
CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3=CC(=C(C=C3CC2C(=O)O)OC)OC.Cl
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InChi
InChI=1S/C27H34N2O7.ClH/c1-5-36-27(33)21(12-11-18-9-7-6-8-10-18)28-17(2)25(30)29-16-20-15-24(35-4)23(34-3)14-19(20)13-22(29)26(31)32;/h6-10,14-15,17,21-22,28H,5,11-13,16H2,1-4H3,(H,31,32);1H/t17-,21-,22-;/m0./s1
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InChi Key
JXRAXHBVZQZSIC-JKVLGAQCSA-N
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MSDS Available
Yes