Human Ghrelin
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Catalog number4990-1000
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Price:
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Size1 mg
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SynonymsHuman Ghrelin (Ser3 modified), Ghrelin, h-Ghrelin, rh-Ghrelin, recombinant human Ghrelin, Ghrelin (Ser3 modified), recombinant Ghrelin, Ghrelin
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Alternative_namesAppetite-regulating hormone, Growth hormone secretagogue, Growth hormone-releasing peptide, Motilin-related peptide, Protein M46Human Ghrelin (Ser3 modified), Ghrelin, h-Ghrelin, rh-Ghrelin, recombinant human Ghrelin, Ghrelin (Ser3 modified), recombinant Ghrelin, Ghrelin
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DescriptionHunger stimulating hormone
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RecombinantNo
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AssaySDS-PAGE
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Activity Specifications test methodBiological activity of ghrelin has not been established. The peptide can be used in ELISA, as a positive control in Western blot analysis, or as a blocking peptide to block antibody activity.
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Molecular Weight3.374 kDa
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Storage Temp-20°C
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Shippinggel pack
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Shelf Life12 months
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AppearanceLyophilized peptide
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Physical form descriptionLyophilized peptide
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Reconstitution InstructionsReconstitute in PBS containing at least 0.1% BSA to a concentration of 1.0 mg/ml.
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Background InformationGhrelin (‘ghre’ is the Proto-Indo-European root of the word ‘grow’) has been identified as the endogenous ligand for the GHS-R (growth hormone secretagogues receptor). Ghrelin is expressed in the stomach, small and large intestines, and brain regions that are involved in the regulation of food intake. Both ghrelin and GHS-R expression is also detected in the heart, suggesting that Ghrelin might have some cardiovascular effects. Ghrelin administration stimulates GH secretion but also causes weight gain by increase food intake. Mature human and rat Ghrelin (28 a.a.) are produced from a 117 amino acid precursor. Ghrelin has an unusual modification at Ser3 residue that is n-octanoylated and is essential for biological activity. Ghrelin is the first known example of a bioactive peptide modified by an acyl acid
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Amino acid sequenceGS(X)FLSPEHQRVQQRKESKKPPAKLQPR X = serine modified with n-octanoic acid
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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Additional descriptionGhrelin, GHRL gene, obestatin prepropeptide or lenomorelin from ghrelinergic cells in the gastrointestinal tract. GHRL is a neuropeptide in the central nervous system regulating appetite. Ghrelin is regulating the distribution and rate of use of body energy.
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Gene target
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Gene symbolGHRL, GHRLOS, MBOAT4
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Short nameGhrelin
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SpeciesHuman, Humans
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Alternative nameH. sapiens Ghrelin
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Gene info
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Identity
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Gene
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Long gene nameghrelin and obestatin prepropeptide
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Synonyms gene name
- ghrelin, growth hormone secretagogue receptor ligand
- ghrelin/obestatin prepropeptide
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2006-01-05
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Neuropeptides
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameghrelin opposite strand/antisense RNA
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Synonyms gene name
- ghrelin opposite strand RNA (non-protein coding)
- ghrelin opposite strand/antisense RNA (non-protein coding)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2007-11-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Long non-coding RNAs with non-systematic symbols
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namemembrane bound O-acyltransferase domain containing 4
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Synonyms gene
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Synonyms gene name
- O-acyltransferase (membrane bound) domain containing 4
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2005-09-27
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Entrez gene record
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Pubmed identfication
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Classification
- Membrane bound O-acyltransferases
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VEGA ID