Human Ghrelin

• Catalog number
  4990-100
• Price
  Please ask
• Size
  100 ug

• Synonyms
  Human Ghrelin (Ser3 modified), Ghrelin, h-Ghrelin, rh-Ghrelin, recombinant human Ghrelin, Ghrelin (Ser3 modified), recombinant Ghrelin, Ghrelin
• Alternative_names
  Appetite-regulating hormone, Growth hormone secretagogue, Growth hormone-releasing peptide, Motilin-related peptide, Protein M46Human Ghrelin (Ser3 modified), Ghrelin, h-Ghrelin, rh-Ghrelin, recombinant human Ghrelin, Ghrelin (Ser3 modified), recombinant Ghrelin, Ghrelin
• Description
  Hunger stimulating hormone
• Recombinant
  No
• Assay
  SDS-PAGE
• Activity Specifications test method
  Biological activity of ghrelin has not been established. The peptide can be used in ELISA, as a positive control in Western blot analysis, or as a blocking peptide to block antibody activity.
• Molecular Weight
  3.374 kDa
• Storage Temp
  -20°C
• Shipping
  gel pack
• Shelf Life
  12 months
• Appearance
  Lyophilized peptide
• Physical form description
  Lyophilized peptide
• Reconstitution Instructions
  Reconstitute in PBS containing at least 0.1% BSA to a concentration of 1.0 mg/ml.
• Background Information
  Ghrelin (‘ghre’ is the Proto-Indo-European root of the word ‘grow’) has been identified as the endogenous ligand for the GHS-R (growth hormone secretagogues receptor). Ghrelin is expressed in the stomach, small and large intestines, and brain regions that are involved in the regulation of food intake. Both ghrelin and GHS-R expression is also detected in the heart, suggesting that Ghrelin might have some cardiovascular effects. Ghrelin administration stimulates GH secretion but also causes weight gain by increase food intake. Mature human and rat Ghrelin (28 a.a.) are produced from a 117 amino acid precursor. Ghrelin has an unusual modification at Ser3 residue that is n-octanoylated and is essential for biological activity. Ghrelin is the first known example of a bioactive peptide modified by an acyl acid
• Amino acid sequence
  GS(X)FLSPEHQRVQQRKESKKPPAKLQPR X = serine modified with n-octanoic acid
• Handling
  Centrifuge the vial prior to opening.
• Usage
  For Research Use Only! Not to be used in humans
• Datasheet
• Additional description
  Ghrelin, GHRL gene, obestatin prepropeptide or lenomorelin from ghrelinergic cells in the gastrointestinal tract. GHRL is a neuropeptide in the central nervous system regulating appetite. Ghrelin is regulating the distribution and rate of use of body energy.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

• Gene target
  Ghrelin  
• Gene symbol
  GHRL, GHRLOS, MBOAT4
• Short name
  Ghrelin
• Species
  Human, Humans
• Alternative name
  H. sapiens Ghrelin

Gene info

• Identity
  HGNC:18129
• Gene
  GHRL
• Long gene name
  ghrelin and obestatin prepropeptide
• Synonyms gene name
  • ghrelin, growth hormone secretagogue receptor ligand
  • ghrelin/obestatin prepropeptide
• Synonyms
  • MTLRP
  • ghrelin
  • obestatin
• Synonyms name
  • prepro-appetite regulatory hormone
• GenBank acession
  • AF296558
• Locus
  3p25.3
• Discovery year
  2006-01-05
• Entrez gene record
  51738
• Pubmed identfication
  • 10930375
  • 10604470
  • 16284174
• RefSeq identity
  • NM_016362
• Classification
  • Neuropeptides
• VEGA ID
  OTTHUMG00000155360

Gene info

• Identity
  HGNC:33885
• Gene
  GHRLOS
• Long gene name
  ghrelin opposite strand/antisense RNA
• Synonyms gene name
  • ghrelin opposite strand RNA (non-protein coding)
  • ghrelin opposite strand/antisense RNA (non-protein coding)
• Synonyms
  • NCRNA00068
  • GHRL-AS1
• Synonyms name
  • non-protein coding RNA 68
  • GHRL antisense RNA 1 (non-protein coding)
• GenBank acession
  • EF549568
• Locus
  3p25.3
• Discovery year
  2007-11-20
• Entrez gene record
  100126793
• Pubmed identfication
  • 17727735
  • 18954468
• RefSeq identity
  • NR_004431
• Classification
  • Long non-coding RNAs with non-systematic symbols
• VEGA ID
  OTTHUMG00000155359

Gene info

• Identity
  HGNC:32311
• Gene
  MBOAT4
• Long gene name
  membrane bound O-acyltransferase domain containing 4
• Synonyms gene
  • OACT4
• Synonyms gene name
  • O-acyltransferase (membrane bound) domain containing 4
• Synonyms
  • FKSG89
  • GOAT
• Synonyms name
  • ghrelin O-acyltransferase
• GenBank acession
  • AF359269
• Locus
  8p12
• Discovery year
  2005-09-27
• Entrez gene record
  619373
• Pubmed identfication
  • 18443287
• Classification
  • Membrane bound O-acyltransferases
• VEGA ID
  OTTHUMG00000163824

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