DAP12 Antibody

• Catalog number
  5570R-30T
• Price
  Please ask
• Size
  30 µg

• Antibody Target
  DAP12
• Target Alternative Name
  DAP-12, DAP 12, DAP12, TYRO protein tyrosine kinase binding protein , TYROBP
• Antibody Type
  Polyclonal
• Species Reactivities
  Human
• Immunogen Sequence
  Synthetic peptide corresponding to residues surrounding amino acids 94 of mouse DAP-12
• Accession
  O54885
• Gene Id
  22177
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  0.5 mg/ml
• Formulation
  Supplied in PBS, pH 7.2, 30% glycerol, 0.5% BSA, 0.5 mM EDTA and 0.03% proclin
• Purification
  Affinity purified
• Application
  Western blot
• Application And Usages
  Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually.
• Description
  DAP12 (KARAP) is a natural killer (NK) cell-expressed cell surface receptor and belongs to the immunoglobulin and C-type lectin superfamily. Unlike other members of this family which possess immunoreceptor tyrosine-based inhibitory motifs (ITIM), DAP12 contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain and is present as a disulphide-bonded homodimer. Crosslinking of DAP 12-KIR complexes (membrane glycoproteins of the killer-cell inhibitory receptor family without an ITIM in their cytoplasmic domain) results in cellular activation.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  DAP12  
• Gene symbol
  TYROBP
• Short name
  DAP12 Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  DAP12 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:12449
• Gene
  TYROBP
• Long gene name
  transmembrane immune signaling adaptor TYROBP
• Synonyms gene
  • PLOSL
• Synonyms gene name
  • polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
  • TYRO protein tyrosine kinase binding protein
• Synonyms
  • DAP12
  • PLO-SL
  • KARAP
• Synonyms name
  • killer activating receptor associated protein
  • DNAX-activation protein 12
  • DNAX adaptor protein 12
• GenBank acession
  • AF019563
• Locus
  19q13.12
• Discovery year
  1998-06-25
• Entrez gene record
  7305
• Pubmed identfication
  • 9490415
  • 10888890
• VEGA ID
  OTTHUMG00000181739
• Locus Specific Databases
  • LRG_607

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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