DAP12 Antibody

• Catalog number
  bs-12630R
• Price
  Please ask
• Size
  0.1ml

• Long name
  DAP12 Primary Polyclonal Antibody
• Also known as
  DAP12 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  DAP12
• Specificity
  This is a highly specific antibody against DAP12.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human DAP12
• Tested Applications
  WB, FCM, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  DAP 12; DAP12; DNAX activation protein 12; DNAX-activation protein 12; KAR-associated protein; KARAP; Killer activating receptor associated protein; Killer-activating receptor-associated protein; PLOSL; TYOBP_HUMAN; TYRO protein tyrosine kinase binding protein; TYRO protein tyrosine kinase-binding protein; TYROBP.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  DAP12  
• Gene symbol
  TYROBP
• Short name
  Anti-DAP12
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  DAP12 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:12449
• Gene
  TYROBP
• Long gene name
  transmembrane immune signaling adaptor TYROBP
• Synonyms gene
  • PLOSL
• Synonyms gene name
  • polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
  • TYRO protein tyrosine kinase binding protein
• Synonyms
  • DAP12
  • PLO-SL
  • KARAP
• Synonyms name
  • killer activating receptor associated protein
  • DNAX-activation protein 12
  • DNAX adaptor protein 12
• GenBank acession
  • AF019563
• Locus
  19q13.12
• Discovery year
  1998-06-25
• Entrez gene record
  7305
• Pubmed identfication
  • 9490415
  • 10888890
• VEGA ID
  OTTHUMG00000181739
• Locus Specific Databases
  • LRG_607

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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