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Alternative_name
(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
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Description
Cell-permeable. An Antioxidant, anti-inflammatory and immunosuppressive agent. Suppresses LPS-induced cytokine release in macrophages and monocytes (IC₅₀ = 40 nM for IL-1β and IL-1α, 80 nM for IL-6, 110 nM for prostaglandin E2 and 210 nM for IL-8 and TNF-α). Suppresses nitric oxide (NO) production (IC₅₀ = 230 nM) and LPS-induced NF-κB activation (IC₅₀ = 270 nM). Inhibits chymotrypsin-like activity of 20S proteasome (IC₅₀ = 2.5 µM) and lipid peroxidation induced by ADP and Fe²⁺ in rat liver mitochondria (IC₅₀ = 7 µM).
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CAS Number
34157-83-0
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₉H₃₈O₄
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Molecular Weight
450.61
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Cell Permeable
Yes
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Purity
≥98% by TLC
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Solubilities
DMSO (45 mg/ml) or Ethanol (30 mg/ml)
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Handling
Protect from air and moisture
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Tag Line
An Antioxidant, anti-inflammatory and immunosuppressive agent
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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MDL Number
MFCD03424073
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PubChem CID
122724
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SMILES
CC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C)O
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InChi
InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1
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InChi Key
KQJSQWZMSAGSHN-JJWQIEBTSA-N
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MSDS Available
Yes