Caspase-13 Inhibitor LEED-FMK

  • Catalog number
    1115-100
  • Price
    187.31 USD
  • Size
    100 ul (2 mM)
  • Alternative_name
    Z-LEED-FMK, Z-LEED-fluoromethylketone, Caspase-13 Inhibitor (fluoromethylketone)
  • Description
    A synthetic peptide inhibitor that inhibits caspase-13 and related caspase activity. FMK inhibitors are irreversible and non-toxic, and can be used in both in vivo and in vitro studies. The inhibitor is designed as a methyl ester to facilitate cell permeability. (CAUTION: If the intended use is on purified or recombinant enzymes, esterase should be added to generate free carboxyl groups).
  • Structure Available
    No
  • Peptide sequence
    Z-Leu-Glu(OMe)-Glu(OMe)-Asp(OMe)-FMK
  • Salt Form
    No
  • Molecular Formula
    C₃₂H₄₅FN₄O₁₂
  • Molecular Weight
    696.7
  • Cell Permeable
    Yes
  • Purity
    >95% by HPLC
  • Handling
    Protect from light and moisture
  • Tag Line
    A caspase-13 inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    12 months
  • MDL Number
    MFCD03453602
  • PubChem CID
    44135223
  • SMILES
    CC(C)CC(C(=O)NC(CCC(=O)OC)C(=O)NC(CCC(=O)OC)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1
  • InChi
    InChI=1S/C32H45FN4O12/c1-19(2)15-24(37-32(45)49-18-20-9-7-6-8-10-20)31(44)35-21(11-13-26(39)46-3)29(42)34-22(12-14-27(40)47-4)30(43)36-23(25(38)17-33)16-28(41)48-5/h6-10,19,21-24H,11-18H2,1-5H3,(H,34,42)(H,35,44)(H,36,43)(H,37,45)
  • InChi Key
    JQWJGEBRHHCICO-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Additional description
    Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways. Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
MeSH Data
  • Name
  • Concept
    Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
  • Tree numbers
    • E05.599.495
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