BAY-598
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Catalog numberB2667-25
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PricePlease ask
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Size25 mg
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Alternative_nameBAY598, (S,E)-N-(1-(N'-cyano-N-(3-(difluoromethoxy)phenyl)carbamimidoyl)-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl)-N-ethyl-2-hydroxyacetamide
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DescriptionBAY-598 is a potent and selective competitive inhibitor of SMYD2 lysine methyltransferase (IC₅₀ values are 27 and 58 nM for biochemical and cellular activity assays, respectively). It displays >100-fold selectivity for SMYD2 over a panel of 32 other methyltransferases including SMYD3, SUV420H1, and SUV420H2. Decreases p53K370me levels in HEK293 cells. Reduces methylation in tumor cells in a mouse xenograft model.
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CAS Number1906919-67-2
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₂H₂₀Cl₂F₂N₆O₃
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Molecular Weight525.34
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Cell PermeableTrue
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Purity≥98% by HPLC
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Solubilities>40 mg/ml DMSO
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HandlingDo not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
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Tag LineA potent, selective and competitive inhibitor of SMYD2 lysine methyltransferase
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Storage Condition-20ºC
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Shipping ConditionGel Pack
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Shelf Life36 months
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PubChem CID117072551
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SMILESCCN(C1CN(N=C1C2=CC(=C(C=C2)Cl)Cl)C(=NC3=CC(=CC=C3)OC(F)F)NC#N)C(=O)CO
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InChiInChI=1S/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13)22(28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3,(H,28,29)/t18-/m0/s1
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InChi KeyOTTJIRVZJJGFTK-SFHVURJKSA-N
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MSDS Available1
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Gene target
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Gene symbolMIR598
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Short nameBAY-598
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Alternative nameBAY-598
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Gene info
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Identity
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Gene
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Long gene namemicroRNA 598
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Synonyms gene
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Synonyms
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Locus
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Discovery year2006-05-16
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Entrez gene record
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RefSeq identity
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Classification
- MicroRNAs