BAY-1895344 hydrochloride
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Catalog number
B1962-5
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Price
Please ask
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Size
5 mg
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Alternative_name
(R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine hydrochloride
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Description
BAY-1895344, an orally available, potent ATR (ataxia telangiectasia and Rad3-related) protein inhibitor (IC₅₀ = 7 nM). Displays potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride.
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CAS Number
1876467-74-1 (free base)
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₀H₂₂ClN₇O
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Molecular Weight
411.89
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO
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Handling
Protect from air and light
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Tag Line
A potent ATR (ataxia telangiectasia and Rad3-related) protein inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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PubChem CID
118869362
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SMILES
CC1COCCN1C2=NC3=C(C=CN=C3C4=CC=NN4)C(=C2)C5=CC=NN5C
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InChi
InChI=1S/C20H21N7O/c1-13-12-28-10-9-27(13)18-11-15(17-5-8-23-26(17)2)14-3-6-21-20(19(14)24-18)16-4-7-22-25-16/h3-8,11,13H,9-10,12H2,1-2H3,(H,22,25)/t13-/m1/s1
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InChi Key
YBXRSCXGRPSTMW-CYBMUJFWSA-N
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MSDS Available
Yes
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