AT9283
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Catalog number2432-5
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PricePlease ask
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Size5 mg
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Alternative_name1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea
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DescriptionA pan-Aurora kinase inhibitor (IC₅₀ = 3 nM for both Aurora A and B). AT9283 also potently inhibits several kinases including the JAK2 and 3 (IC₅₀’s 1.2 and 1.1 nM, respectively), c-Abl(IC₅₀ = 110 nM) and Abl/T315I (IC₅₀ = 4 nM).
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CAS Number896466-04-9
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₉H₂₃N₇O₂
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Molecular Weight381.43
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>70 mg/ml) or EtOH (>25 mg/ml)
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HandlingProtect from light and air
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Tag LineA multi-targeted c-Abl, JAK2, Aurora A and B inhibitor
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Storage Condition-20 ̊C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID11696609
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SMILESC1CC1NC(=O)NC2=CNNC2=C3N=C4C=CC(=CC4=N3)CN5CCOCC5
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InChiInChI=1S/C19H23N7O2/c27-19(21-13-2-3-13)24-16-10-20-25-17(16)18-22-14-4-1-12(9-15(14)23-18)11-26-5-7-28-8-6-26/h1,4,9-10,13,20,25H,2-3,5-8,11H2,(H2,21,24,27)/b18-17-
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InChi KeyVRXXZJLHPWWXIX-ZCXUNETKSA-N
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MSDS AvailableYes
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Gene target
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Short nameAT9283
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Alternative nameAT9283
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