Anti-HER2 (Trastuzumab), Humanized Antibody

• Catalog number
  A1046-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  HER2
• Target Alternative Name
  Neu, Ngl, Erbb2, Tkr1, Cd340, Her-2, Mln 19, HER-2/neu, RHUMAB HER2, 4D5V8, ABP 980, ABP-980, DMB-3111, EG-12014, EG12014, R-597, SB-3, SYD-977, SYD977
• Antibody Type
  Monoclonal
• Species Reactivities
  Human
• Immunogen Sequence
  Recombinant human epidermal growth factor receptor 2 (HER2)
• Accession
  P04626.
• Gene Id
  2064
• Appearance
  Colourless liquid
• Form
  Liquid
• Concentration
  2 mg/ml
• Formulation
  100 ug (2 mg/ml) of antibody in Phosphate buffered saline, pH 7.4.
• Purification
  human IgG1 was expressed in a human cell line. IgG was purified from CHO cell culture supernatant by protein A chromatography.
• Application
  Neutralization, ELISA
• Application And Usages
  Neutralization : 1-20 μg/ml; ELISA: 2μg/ml
• Description
  Trastuzumab is a recombinant humanized monoclonal immunoglobulin G1 kappa antibody that binds with high affinity and specificity to the extracellular domain of the HER2 receptor. A growth factor receptor gene, human epidermal growth factor receptor (HER2), is amplified in 25 to 30 % of breast cancers and in these cases the encoded protein is present in abnormally high levels in the malignant cells. Trastuzumab is used to treat adjuvant and metastatic breast cancer as well as metastatic gastric cancer.
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans
• Handling
  The antibody solution should be gently mixed before use
• Western Blot Verified
  Not Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  HER2   Trastuzumab   Humanized  
• Gene symbol
  ERBB2
• Short name
  Anti-HER2 (Trastuzumab), Humanized Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  Human IgG1
• Alternative name
  Antibody toHER2 (Trastuzumab), Humanized (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:3430
• Gene
  ERBB2
• Long gene name
  erb-b2 receptor tyrosine kinase 2
• Synonyms gene
  • NGL
• Synonyms gene name
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
• Synonyms
  • NEU
  • HER-2
  • CD340
  • HER2
• Synonyms name
  • neuro/glioblastoma derived oncogene homolog
  • human epidermal growth factor receptor 2
• GenBank acession
  • X03363
• Locus
  17q12
• Discovery year
  2001-06-22
• Entrez gene record
  2064
• RefSeq identity
  • NM_004448
• Classification
  • Erb-b2 receptor tyrosine kinases
  • CD molecules
  • Minor histocompatibility antigens
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000179300
• Locus Specific Databases
  • LRG_724

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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