Anti-HER2 (Pertuzumab), Humanized Antibody

• Catalog number
  A2111-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  HER2
• Target Alternative Name
  2C4, rhuMAb-2C4, HER2, HER-2, HER 2, Neu, Ngl, Erbb2, Tkr1, Cd340, Mln 19, HER-2/neu
• Antibody Type
  Monoclonal
• Immunogen Sequence
  Pertuzumab
• Accession
  DB06366
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  In PBS buffer, pH 7.2
• Application
  Growth inhibition assay, Cell cytotoxicity assay, In vivo studies
• Application And Usages
  Growth inhibition assay, Cell Cytotoxicity assay, In vivo studies
• Description
  Pertuzumab is a humanized monoclonal antibody that is produced by recombinant DNA technology in CHO cells and targets the extracellular domain of human epidermal growth factor receptor 2 (HER2) by blocking the binding pocket required for dimerization of the receptor and receptor mediated signaling. This prevents binding of HER2 with other HER family members (HER1, HER3, HER4) and thus inhibits cancer cell growth. Developed by Roche and Genentech, Pertuzumab was approved by FDA in 2012 to treat advanced breast cancer. Combination treatment with Trastuzumab and Docetaxel has been recommended for treating patients that have HER2-positive metastatic breast cancer.
• Storage Condition
  4°C
• Shipping Condition
  Gel Pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  HER2   Pertuzumab   Humanized  
• Gene symbol
  ERBB2
• Short name
  Anti-HER2 (Pertuzumab), Humanized Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  Human IgG1
• Alternative name
  Antibody toHER2 (Pertuzumab), Humanized (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:3430
• Gene
  ERBB2
• Long gene name
  erb-b2 receptor tyrosine kinase 2
• Synonyms gene
  • NGL
• Synonyms gene name
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
• Synonyms
  • NEU
  • HER-2
  • CD340
  • HER2
• Synonyms name
  • neuro/glioblastoma derived oncogene homolog
  • human epidermal growth factor receptor 2
• GenBank acession
  • X03363
• Locus
  17q12
• Discovery year
  2001-06-22
• Entrez gene record
  2064
• RefSeq identity
  • NM_004448
• Classification
  • Erb-b2 receptor tyrosine kinases
  • CD molecules
  • Minor histocompatibility antigens
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000179300
• Locus Specific Databases
  • LRG_724

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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