Anti-CTLA-4 (Ipilimumab), Humanized Antibody

Antibody Target

CTLA-4
Target Alternative Name

MDX-010, BMS-734016, CTLA-4, CTLA 4, CTLA4, Yervoy
Antibody Type

Monoclonal
Immunogen Sequence

Ipilimumab
Accession

DB06186
Appearance

Colorless liquid
Form

Liquid
Formulation

In PBS buffer, pH 7.2
Application

In vivo studies,Cell proliferation assay
Application And Usages

Cell proliferation assay, In vivo studies
Description

Iplimumab is a fully humanized IgG1 monoclonal antibody that targets cytotoxic T-lymphocyte antigen 4 (CTLA-4). By binding to CTLA-4, it releases the inhibitory action on cytotoxic T-lymphocytes and thus results in destruction of cancer cells. Developed by Bristol-Myers Squibb and Medarex, Iplimumab (Yervoy) was approved by FDA in 2011 to treat metastatic melanoma, metastatic colorectal cancer, and hepatocellular carcinoma. Combination therapy with Nivolumab has been recommended for advanced renal cell carcinoma
Storage Condition

4°C
Shipping Condition

Gel Pack
Shelf Life

12 months
Usage

For Research Use Only! Not to be used in humans.
Handling

The antibody solution should be gently mixed before use.
Data Sheet Link
Additional description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
Properties

If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation

anticorps

Gene target

CTLA-4 Ipilimumab Humanized
Gene symbol

CTLA4, MIR1302-4, PIRC18, PIRC16, SNORD114-4, MIR941-4, IGKV2OR2-4, ANKRD20A12P
Short name

Anti-CTLA-4 (Ipilimumab), Humanized Antibody
Technique

Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
Isotype

Human IgG1
Alternative name

Antibody toCTLA-4 (Ipilimumab), Humanized (antibody to-)
Alternative technique

antibodies

Identity

HGNC:5809
Gene

IGKV2OR2-4
Long gene name

immunoglobulin kappa variable 2/OR2-4 (pseudogene)
Synonyms gene name
- immunoglobulin kappa variable 2/OR2-4
- immunoglobulin kappa variable 2/OR2-4 pseudogene
Synonyms
- IGKV2/OR2-4
GenBank acession
- X51883
Locus

2q11.2
Discovery year

2000-04-18
Entrez gene record

28858
Pubmed identfication
- 2111145
Classification
- Immunoglobulin kappa (IGK) orphons

Name

Blotting, Western
Concept

Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
Qualifiers

ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data