Anti-CD4 (Ibalizumab), Humanized Antibody

• Catalog number
  A2251-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  CD4
• Target Alternative Name
  CD4mut, CD4, CD4 Molecule, T-Cell Surface Glycoprotein CD4, T-Cell Surface Antigen T4/Leu-3, CD4 Antigen (P55), CD4 Receptor, CD4 Antigen
• Antibody Type
  Monoclonal
• Species Reactivities
  Human
• Immunogen Sequence
  Human CD4
• Accession
  DB12698
• Gene Id
  920
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  In PBS, pH 7.5
• Purification
  Protein A purified
• Description
  The research-grade biosimilar is a humanized monoclonal antibody that targets CD4. CD4 is a primary receptor for the human immunodeficiency virus (HIV-1). HIV-1 enters target cells by binding to CD4 via envelope glycoprotein (gp120). As a result, the CD4/gp120 complex enables the binding of gp120 to another cell receptor CCR5 or CXCR4. This interaction allows gp41 mediated fusion of viral envelope with the target cell membrane. The monoclonal antibody does inhibit the interaction of gp120 with CD4; it binds to an epitope located in domain 2 of the extracellular portion of CD4. This binding induces a conformational change and prevents the binding of gp120 with CCR5 or CXCR4. The antibody belongs to the sub-class of HIV drugs called entry inhibitors or post attachment inhibitors. The original monoclonal antibody is approved by the FDA either alone or in combination with other antiretroviral drugs to treat patients with multi-drug resistance to HIV-1
• Storage Condition
  -80ºC
• Shipping Condition
  Gel Pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use. CD4+ T helper cell marker or cluster differentiator of white blood cells in FACS or flow cytometry. Used offer coupled to magnetic beads. GENTAUR makes custom magnetic bead couplings on 50 and 250 nm beads for certain clones.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CD4   Ibalizumab   Humanized  
• Gene symbol
  CD4
• Short name
  Anti-CD4 (Ibalizumab), Humanized Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  IgG4, kappa
• Alternative name
  Antibody toCD4 (Ibalizumab), Humanized (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  CD4 molecule, CD4mut, CD4 and IDBG-15034 and ENSG00000010610 and 920, protein homodimerization activity, Cell surfaces, Cd4 and IDBG-188351 and ENSMUSG00000023274 and 12504, CD4 and IDBG-640247 and ENSBTAG00000003255 and 407098

Gene info

• Identity
  HGNC:1678
• Gene
  CD4
• Long gene name
  CD4 molecule
• Synonyms gene name
  • CD4 antigen (p55)
  • T-cell surface glycoprotein CD4
• GenBank acession
  • M35160
• Locus
  12p13.31
• Discovery year
  1986-01-01
• Entrez gene record
  920
• RefSeq identity
  • NM_000616
• Classification
  • CD molecules
  • C2-set domain containing
  • V-set domain containing
• VEGA ID
  OTTHUMG00000168514

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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