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Alternative_name
(2R)-2-[[9-Isopropyl-6-(N-methylanilino)purin-2-yl]amino]butan-1-ol; Amyloidβ Forty-Two Inducer 5
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Description
Roscovitine-related purine with no activity on CDKS. Selectively and potently increases production of extracellular Aβ42 and decreases production of extracellular Aβ38 in cultured cells. Extracellular Aβ40 levels remain stable. Intracellular levels of these amyloids appear to remain stable. Alzheimer's Disease (AD) accelerator that interacts with VDAC1, prohibitin and mitofilin, possibly interfering with subcellular compartmentalization and lipid rafts properties, shifting γ-secretase activity toward Aβ42 generation. Induces a reversible mitochondrial phenotype reminiscent of the one observed in AD brains.
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Structure Available
Y
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Salt Form
No
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Molecular Formula
C₁₉H₂₆N₆O
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Molecular Weight
354.45
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Cell Permeable
Yes
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Purity
≥98% by NMR
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Solubilities
DMSO or EtOH
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Handling
Protect from air and light
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Tag Line
An amyloid-β42 Inducer
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Storage Condition
-20°C
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Shipping Condition
Gel pack
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Shelf Life
24 months
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SMILES
CC(C)N1C2=NC(N[C@@H](CO)CC)=NC(N(C)C3=CC=CC=C3)=C2N=C1
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InChi
InChI=1S/C19H26N6O/c1-5-14(11-26)21-19-22-17(24(4)15-9-7-6-8-10-15)16-18(23-19)25(12-20-16)13(2)3/h6-10,12-14,26H,5,11H2,1-4H3,(H,21,22,23)/t14-/m1/s1
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InChi Key
HYFZLABHJHEEFS-CQSZACIVSA-N
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MSDS Available
Yes