Recombinant Human HtrA3, His - tagged (Recombinant Protein)

• Catalog number
  30 600 502
• Price
  Please ask
• Size
  5 µg/ 50 µl

• Protein type
  Recombinant
• Protein subtype
  EC 3.4.21.108
• Protein family
  Member of the trypsin family of serine proteases
• Protein description
  HtrA3 is a serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization
• Research area interests
  Diseases associated with HTRA3 include Vitreoretinopathy, Neovascular Inflammatory and Purulent Acute Otitis Media, Preeclampsia
• Package form
  liquid
• Tested applications
  Characterization of structure and function; Screening of inhibitors; Standard in enzymatic and immunologiacal assays
• Other names
  High-Temperature Requirement Factor A3, Pregnancy-Related Serine Protease
• Peptide sequence
  MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIIHHHHHH
• Available target modification
  No
• Expression system
  Insect Cell
• Product Subtype
  full length
• Active form
  Yes
• Tag
  His-tagged
• Contents
  150 mM NaCl, 5 mM CaCl2, 0.05 % Brij-35, 50 mM imidazol, 50 mM Tris-HCl, pH 7.5.
• Protein purity
  > 70 %
• Molecular weight
  50 kDa
• UniProt number
  P83110
• Gene number
  94031
• Abbreviation
  HTRA3
• Full name
  HtrA serine peptidase 3
• Other desciption
  Recombinant human HtrA3 is expressed in insect cells with a C-terminal His-tag and purified from insect cell culture supernatants
• Purification
  Mentioned in the data sheet
• PubMed citations
  See the data sheet
• Warnings
  For Research Use only.
• Shipping conditions
  dry ice
• Storage condition
  Store at -70°C
• Technical datasheet
  Contact us to receive the datasheet
• Representative figure
  more details
• Other products
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  HtrA3   His    tagged   Protein  
• Short name
  Recombinant HtrA3, His - tagged (Recombinant Protein)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. biotez advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Label
  His
• Species
  Homo sapiens, Humans
• Alternative name
  Rec. H. sapiens HtrA3, histidine - tagged (Rec. Protein)
• Alternative technique
  rec

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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