Recombinant Human ADAMTS4 (Aggrecanase1), truncated, His-tagged (Recombinant Protein)

• Catalog number
  30 400 103
• Price
  Please ask
• Size
  100 µg/500 µl

• Protein type
  Recombinant
• Protein subtype
  EC 3.4.24
• Protein family
  ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family.
• Protein description
  ADAMTS4 cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the 392-Glu- -Ala-393 site.
• Research area interests
  Diseases associated with ADAMTS4 include Chondrosarcoma. Among its related pathways are Diseases associated with O-glycosylation of proteins and Transport to the Golgi and subsequent modification.
• Package form
  liquid
• Tested applications
  Degradation of extracellular matrix proteoglycans; screening and characterization of inhibitors; Standard in enzymatic and immunological assays
• Other names
  A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 4; ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5
• Peptide sequence
  F A S L S R F V E T L V V A D D K M A A F H G A G L K R Y L L T V M A A A A K A F K H P S I R N P V S L V V T R L V I L G S G E E G P Q V G P S A A Q T L R S F C A W Q R G L N T P E D S D P D H F D T A I L F T R Q D L C G V S T C D T L G M A D V G T V C D P A R S C A I V E D D G L Q S A F T A A H E L G H V F N M L H D N S K P C I S L N G P L S T S R H V M A P V M A H V D P E E P W S P C S A R F I T D F L D N G Y G H C L L D K P E A P L H L P V T F P G K D Y D A D R Q C Q L T F G P D S R H C P Q L P P P C A A L W C S G H L N G H A M C Q T K H S P W A D G T P C G P A Q A C M G G R C L H M D Q L Q D F N I P Q A G G W G P W G P W G D C S R T C G G G V Q F S S R D C T R P V P R N G G K Y C E G R R T R F R S C N T E D C P T G S A (H)6
• Available target modification
  No
• Expression system
  Insect Cell
• Product Subtype
  protein fragment
• Active form
  Yes
• Tag
  His-tagged
• Contents
  50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2, 0.05 % Brij-35 Detergent
• Protein purity
  > 90 %
• Molecular weight
  42 kDa
• UniProt number
  O75173
• Gene number
  9507
• Abbreviation
  ADAMTS4 (partial)
• Full name
  ADAM metallopeptidase with thrombospondin type 1 motif 4 (partial)
• Other desciption
  Recombinant human ADAMTS4 Δ580-837 is produced with the baculovirus expression system and purified from insect cell culture supernatants
• Purification
  Mentioned in the data sheet
• PubMed citations
  See the data sheet
• Warnings
  For Research Use only.
• Shipping conditions
  dry ice
• Storage condition
  Store at -70°C
• Technical datasheet
  Contact us to receive the datasheet
• Representative figure
• Other products
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  ADAMTS4   Aggrecanase1   truncated   His-tagged   Protein  
• Gene symbol
  ADAMTS4
• Short name
  Recombinant ADAMTS4 (Aggrecanase1), truncated, His-tagged (Recombinant Protein)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. biotez advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Label
  his-tagged
• Species
  Homo sapiens, Humans
• Alternative name
  Rec. H. sapiens ADAMTS4 (Aggrecanase1), truncated, histidine-tagged (Rec. Protein)
• Alternative technique
  rec

Gene info

• Identity
  HGNC:220
• Gene
  ADAMTS4
• Long gene name
  ADAM metallopeptidase with thrombospondin type 1 motif 4
• Synonyms gene name
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4
• Synonyms
  • KIAA0688
  • ADAMTS-2
  • ADMP-1
• GenBank acession
  • AB014588
• Locus
  1q23.3
• Discovery year
  1999-04-15
• Entrez gene record
  9507
• Pubmed identfication
  • 10094461
• RefSeq identity
  • NM_005099
• Classification
  • ADAM metallopeptidases with thrombospondin type 1 motif
• VEGA ID
  OTTHUMG00000034349

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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