Recombinant Human ADAMTS4 (Aggrecanase1), truncated, His-tagged (Recombinant Protein)
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Catalog number
30 400 102
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Price
Please ask
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Size
5 µg/ 25 µl
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Protein type
Recombinant
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Protein subtype
EC 3.4.24
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Protein family
ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family.
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Protein description
ADAMTS4 cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the 392-Glu- -Ala-393 site.
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Research area interests
Diseases associated with ADAMTS4 include Chondrosarcoma. Among its related pathways are Diseases associated with O-glycosylation of proteins and Transport to the Golgi and subsequent modification.
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Package form
liquid
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Tested applications
Degradation of extracellular matrix proteoglycans; screening and characterization of inhibitors; Standard in enzymatic and immunological assays
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Other names
A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 4; ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4
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Peptide sequence
F A S L S R F V E T L V V A D D K M A A F H G A G L K R Y L L T V M A A A A K A F K H P S I R N P V S L V V T R L V I L G S G E E G P Q V G P S A A Q T L R S F C A W Q R G L N T P E D S D P D H F D T A I L F T R Q D L C G V S T C D T L G M A D V G T V C D P A R S C A I V E D D G L Q S A F T A A H E L G H V F N M L H D N S K P C I S L N G P L S T S R H V M A P V M A H V D P E E P W S P C S A R F I T D F L D N G Y G H C L L D K P E A P L H L P V T F P G K D Y D A D R Q C Q L T F G P D S R H C P Q L P P P C A A L W C S G H L N G H A M C Q T K H S P W A D G T P C G P A Q A C M G G R C L H M D Q L Q D F N I P Q A G G W G P W G P W G D C S R T C G G G V Q F S S R D C T R P V P R N G G K Y C E G R R T R F R S C N T E D C P T G S A (H)6
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Available target modification
No
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Expression system
Insect Cell
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Product Subtype
protein fragment
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Active form
Yes
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Tag
His-tagged
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Contents
50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2, 0.05 % Brij-35 Detergent
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Protein purity
> 90 %
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Molecular weight
42 kDa
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UniProt number
O75173
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Gene number
9507
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Abbreviation
ADAMTS4 (partial)
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Full name
ADAM metallopeptidase with thrombospondin type 1 motif 4 (partial)
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Other desciption
Recombinant human ADAMTS4 Δ580-837 is produced with the baculovirus expression system and purified from insect cell culture supernatants
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Purification
Mentioned in the data sheet
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PubMed citations
See the data sheet
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Warnings
For Research Use only.
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Shipping conditions
dry ice
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Storage condition
Store at -70°C
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Technical datasheet
Contact us to receive the datasheet
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Conjugation
histidine
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
ADAMTS4
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Short name
Recombinant ADAMTS4 (Aggrecanase1), truncated, His-tagged (Recombinant Protein)
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. biotez advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Label
his-tagged
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Species
Homo sapiens, Humans
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Alternative name
Rec. H. sapiens ADAMTS4 (Aggrecanase1), truncated, histidine-tagged (Rec. Protein)
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Alternative technique
rec
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Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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