Recombinant Human ADAMTS1, truncated, His-tagged (Recombinant Protein)

• Catalog number
  30 400 403
• Price
  Please ask
• Size
  100 µg/500 µl

• Protein type
  Recombinant
• Protein subtype
  EC 3.4.24.83
• Protein family
  ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family.
• Protein description
  ADAMTS1 cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.
• Research area interests
  Diseases associated with ADAMTS1 include Type 2A Von Willebrand Disease and Mongolian Spot. Among its related pathways are Diseases associated with O-glycosylation of proteins and Transport to the Golgi and subsequent modification.
• Package form
  liquid
• Tested applications
  Degradation of extracellular matrix proteoglycans; screening and characterization of inhibitors; Standard in enzymatic and immunological assays
• Other names
  A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 1; Human Metalloproteinase With Thrombospondin Type 1 Motifs
• Peptide sequence
  F V S S H R Y V E T M L V A D Q S M A E F H G S G L K H Y L L T L F S V A A R L Y K H P S I R N S V S L V V V K I L V I H D E Q K G P E V T S N A A L T L R N F C N W Q K Q H N P P S D R D A E H Y D T A I L F T R Q D L C G S Q T C D T L G M A D V G T V C D P S R S C S V I E D D G L Q A A F T T A H E L G H V F N M P H D D A K Q C A S L N G V N Q D S H M M A S M L S N L D H S Q P W S P C S A Y M I T S F L D N G H G E C L M D K P H N P I Q L P G D L P G T S Y D A N R Q C Q F T F G E D S K H C P D A A S T C S T L W C T G T S G G V L V C Q T K H F P W A D G T S C G E G K W C I N G K C V N K T D R K H F D T P F H G N W G M W G P W G D C S R T C G G G V Q Y T M R E C D N P V P K N G G K Y C E G K R V R Y R S C N L E D C P D N (H)6
• Available target modification
  No
• Expression system
  Insect Cell
• Product Subtype
  protein fragment
• Active form
  Yes
• Tag
  His-tagged
• Contents
  50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2, 0.05 % Brij-35 Detergent.
• Protein purity
  > 90 %
• Molecular weight
  50 kDa
• UniProt number
  Q9UHI8
• Gene number
  9510
• Abbreviation
  ADAMTS1 (partial)
• Full name
  ADAM metallopeptidase with thrombospondin type 1 motif 1 (partial)
• Other desciption
  Recombinant human ADAMTS1 Δ618-968 is produced with the baculovirus expression system and purified from insect cell culture supernatants.
• Purification
  Mentioned in the data sheet
• PubMed citations
  See the data sheet
• Warnings
  For Research Use only.
• Shipping conditions
  dry ice
• Storage condition
  Store at -70°C
• Technical datasheet
  Contact us to receive the datasheet
• Representative figure
• Other products
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  ADAMTS1   truncated   His-tagged   Protein  
• Gene symbol
  ADAMTS1
• Short name
  Recombinant ADAMTS1, truncated, His-tagged (Recombinant Protein)
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. biotez advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Label
  his-tagged
• Species
  Homo sapiens, Humans
• Alternative name
  Rec. H. sapiens ADAM metallopeptidase including thrombospondin classification 1 motif, 1, truncated, histidine-tagged (Rec. Protein)
• Alternative technique
  rec
• Alternative to gene target
  ADAM metallopeptidase with thrombospondin type 1 motif, 1, C3-C5 and METH1, ADAMTS1 and IDBG-1192 and ENSG00000154734 and 9510, zinc ion binding, Extracellular, Adamts1 and IDBG-173182 and ENSMUSG00000022893 and 11504, ADAMTS1 and IDBG-630287 and ENSBTAG00000000706 and 512171

Gene info

• Identity
  HGNC:217
• Gene
  ADAMTS1
• Long gene name
  ADAM metallopeptidase with thrombospondin type 1 motif 1
• Synonyms gene name
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1
• Synonyms
  • C3-C5
  • METH1
  • KIAA1346
• GenBank acession
  • AF060152
• Locus
  21q21.3
• Discovery year
  1998-11-19
• Entrez gene record
  9510
• Pubmed identfication
  • 10438512
• Classification
  • ADAM metallopeptidases with thrombospondin type 1 motif
• VEGA ID
  OTTHUMG00000078688

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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