SIP1 Antibody

• Catalog number
  bs-9186R
• Price
  Please ask
• Size
  0.1ml

• Long name
  SIP1 Primary Polyclonal Antibody
• Also known as
  SIP1 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  SIP1
• Specificity
  This is a highly specific antibody against SIP1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Subcellular location
  Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SIP1
• Gene ID number
  9839
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  SMAD regulates gene expression by interacting with different classes of transcription factors including DNA-binding multi-zinc finger proteins. SIP1, for SMAD interacting protein 1, is a member of the delta-EF1/Zfh1 family of 2-handed zinc finger/homeodomain proteins. SIP1 contains a SMAD-binding domain, a homeodomain and two clusters of zinc fingers on the N- and C-termini. SIP1, also known as SMADIP1, ZFHX1B and ZEB2 (zinc finger E-box-binding protein 2), can be induced by TGF∫ treatment. SIP1 plays a crucial role in normal embryonic development of neural structures and the neural crest. The human SIP1 gene maps to chromosome 2q22. Mutations in the SIP1 gene cause a form of Hirschsprung disease (HSCR). Patients with SIP1 mutations show mental retardation, delayed motor development, epilepsy, microcephaly, distinct facial features and/or congenital heart disease—all symptoms of HSCR.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Smad Interacting Protein 1 SIP 1; SIP1 SIP-1; Smad-interacting protein 1; SMADIP 1; SMADIP1; ZEB 2; ZEB2; ZEB2_HUMAN; Zfhx1b; ZFHX1B protein; Zfx1b; Zinc finger E box binding protein 2; Zinc finger E-box-binding homeobox 2; Zinc finger homeobox 1b; zinc finger homeobox protein 1; Zinc finger homeobox protein 1b.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SIP1  
• Gene symbol
  GEMIN2, ZEB2, SCAF11
• Short name
  Anti-SIP1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  SIP1 Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:10884
• Gene
  GEMIN2
• Long gene name
  gem nuclear organelle associated protein 2
• Synonyms gene
  • SIP1
• Synonyms gene name
  • survival of motor neuron protein interacting protein 1
  • gem (nuclear organelle) associated protein 2
• GenBank acession
  • AF027150
• Locus
  14q21.1
• Discovery year
  1998-10-16
• Entrez gene record
  8487
• Pubmed identfication
  • 9323130
  • 9323129
  • 11121410
• Classification
  • Gemins
• VEGA ID
  OTTHUMG00000028816

Gene info

• Identity
  HGNC:14881
• Gene
  ZEB2
• Long gene name
  zinc finger E-box binding homeobox 2
• Synonyms gene
  • ZFHX1B
• Synonyms gene name
  • zinc finger homeobox 1b
• Synonyms
  • KIAA0569
  • SIP-1
  • SIP1
• Synonyms name
  • SMAD interacting protein 1
• GenBank acession
  • AB011141
• Locus
  2q22.3
• Discovery year
  2001-03-14
• Entrez gene record
  9839
• RefSeq identity
  • NM_014795
• Classification
  • ZF class homeoboxes and pseudogenes
  • Zinc fingers C2H2-type
• VEGA ID
  OTTHUMG00000187624

Gene info

• Identity
  HGNC:10784
• Gene
  SCAF11
• Long gene name
  SR-related CTD associated factor 11
• Synonyms gene
  • SFRS2IP
  • SRSF2IP
• Synonyms gene name
  • splicing factor, arginine/serine-rich 2, interacting protein
  • serine/arginine-rich splicing factor 2, interacting protein
• Synonyms
  • SIP1
  • SRRP129
  • CASP11
• GenBank acession
  • Y11251
• Locus
  12q12
• Discovery year
  2000-05-05
• Entrez gene record
  9169
• Pubmed identfication
  • 9224939
  • 9447963
• RefSeq identity
  • NM_004719
• Classification
  • Ring finger proteins
• VEGA ID
  OTTHUMG00000149930

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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