SIAH1/2 Antibody

• Catalog number
  bs-3634R
• Price
  Please ask
• Size
  0.1ml

• Long name
  SIAH1/2 Primary Polyclonal Antibody
• Also known as
  SIAH1/2 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  SIAH1/2
• Specificity
  This is a highly specific antibody against SIAH1/2.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  200-250/324
• Subcellular location
  Cytoplasm, Nucleus
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SIAH2
• Gene ID number
  6478, 6477
• Swiss Prot
  O43255, Q8IUQ4
• Tested Applications
  IHC-P, IF(IHC-P)
• Recommended dilutions
  IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Siah2 is a E3 Ubiquitin ligase protein that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targets. Siah2 triggers the ubiquitin-mediated degradation of many proteins, including transcription regulators (e.g. POU2AF1, PML, NCOR1), cell surface receptors (e.g. DCC), antiapoptotic proteins (e.g. BAG1), and proteins involved in synaptic vesicle function in neurons (e.g. SYP). Siah2 has some overlapping function with SIAH1 but is able to trigger the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Seven in Absentia Homolog 2; Ubiquitin Ligase Siah2; SIAH2_HUMAN; E3 ubiquitin-protein ligase SIAH2; Seven in absentia homolog 2; Siah-2; hSiah2; Siah-1; Siah-1a; E3 ubiquitin-protein ligase SIAH1; Seven in absentia homolog 1.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SIAH1/2  
• Gene symbol
  SIAH1
• Short name
  Anti-SIAH1/2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  SIAH1/2 Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  siah E3 ubiquitin protein ligase 1, SIAH1A, SIAH1 and IDBG-30112 and ENSG00000196470 and 6477, ligase activity, nuclei, BT.37798 and IDBG-631496 and ENSBTAG00000010868 and 534655

Gene info

• Identity
  HGNC:10857
• Gene
  SIAH1
• Long gene name
  siah E3 ubiquitin protein ligase 1
• Synonyms gene name
  • seven in absentia homolog 1 (Drosophila)
• Synonyms
  • hSIAH1
• GenBank acession
  • U76247
• Locus
  16q12.1
• Discovery year
  1997-09-12
• Entrez gene record
  6477
• Pubmed identfication
  • 9403064
  • 9334332
• Classification
  • Ring finger proteins
• VEGA ID
  OTTHUMG00000175417

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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