SH3KBP1 Antibody

• Catalog number
  bs-6239R
• Price
  Please ask
• Size
  0.1ml

• Long name
  SH3KBP1 Primary Polyclonal Antibody
• Also known as
  SH3KBP1 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  SH3KBP1
• Specificity
  This is a highly specific antibody against SH3KBP1.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SH3KBP1
• Gene ID number
  30011
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  SH3KBP1 belongs to the CIN85/CMS family of adaptor molecules, characterized by containing three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The different members of the family orchestrate a network involved in dowregulation and degradation of recpetor tyrosine kinases. SH3KBP1 is involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. In the case of EGF receptor turnover, its activation involves recruitment of SH3KBP1- endophilin complexes to mediate internalization. Once internalized, RTKs are delivered into the endosomal compartment where receptors get sorted for either recycling back to the cell surface or are targeted to lysosomes for degradation. Alternate splicing results in multiple transcript variants.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Cbl interacting protein; Cbl interacting protein of 85 kDa; CD2 binding protein 3; CD2BP3; CIN 85; CIN85; GIG 10; GIG10; HSB 1; Human Src family kinase binding protein 1; MIG 18; MIG18; Migration inducing gene 18 protein; SH3 domain kinase binding protein 1; SH3BP 1; Src family kinase binding protein 1; src related kinase binding protein 1; SH3K1_HUMAN.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SH3KBP1  
• Gene symbol
  SH3KBP1
• Short name
  Anti-SH3KBP1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  SH3KBP1 Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  SH3-domain kinase binding protein 1, SH3KBP1 and IDBG-49936 and ENSG00000147010 and 30011, SH3 domain binding, Cell surfaces, Sh3kbp1 and IDBG-182475 and ENSMUSG00000040990 and 58194, BT.104277 and IDBG-638563 and ENSBTAG00000003727 and 510489

Gene info

• Identity
  HGNC:13867
• Gene
  SH3KBP1
• Long gene name
  SH3 domain containing kinase binding protein 1
• Synonyms
  • CIN85
• GenBank acession
  • AF230904
• Locus
  Xp22.12
• Discovery year
  2000-12-14
• Entrez gene record
  30011
• Pubmed identfication
  • 8889549
  • 7566098
• RefSeq identity
  • NM_031892
• VEGA ID
  OTTHUMG00000021227
• Locus Specific Databases
  • Global Variome shared LOVD

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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